Shared Flashcard Set

Details

Ceutics
Administration
30
Health Care
Professional
12/11/2010

Additional Health Care Flashcards

 


 

Cards

Term

T/F

 

Iontophoresis allows for the andministration of a lower dose than oral and less toxicity

Definition
TRUE
Term
In Phonophoresis, the drug is mixed with____
Definition
coupling agent (gel, cream, ointment)
Term
A fast dissolving tablet should be administed via____
Definition
Buccal cavity
Term
What are some theories to keep drugs in the stomach for a longer time?
Definition
Making expandable or floatable tablets
Term
Enteric coated tablets break up in a _____environment
Definition
basic
Term
Why do some drugs have colon-specific delivery?
Definition

to treat colon-related diseases (IBS, Uclerative Colitis)

 

To get systemic absorption of proteins and peptides 

Term
What are the 4 types of colon specific deliverys systems?
Definition
PRodrugs, pH dependent, time dependent, bacterial eznyme dependent
Term
What is a potential problem with drugs dependent on bacterial enzymes in the colon?
Definition
Colonic flora is dependent on diet, use of abx etc
Term
What effect do extended release drugs have on max concentration, absorption, toxicity, and AUC?
Definition

max concentration is decrease

absorption is increased

toxicity is decreased

AUC is greater

Term
How do oral adhesive systems work?
Definition
The mucus has a net (-) charge and the polymers have a (+) charge and are attracted to eachother
Term
Oral adhesive drugs must be effective in____concetrations
Definition
Very small (ng)
Term
For vaginal delivery systems the dosage must be _____to administer for long periods of time
Definition
low
Term

T/F

Vaginal delivery systems can last from 12hrs to one year depending on the drug

Definition

TRUE

 

Progestasert (one yr)

Dinoprostone (12hrs)

Term
Why do we use gels for opthalmics?
Definition
It is a viscosity increasing agent that increases corneal contact time
Term
What equation can be used to determine the drug release of Pilocarpine insert.
Definition

Noyes-Whitney equation

 

dM= DSKΔC

dt       h    

Term
What is the difference between liposomes and micelles?
Definition

Micelles have a hydrophobic interior

 

Liposomes have a hydrophilic interior

Term
What are the advantages of liposomes for parenteral delivery?
Definition

site specific target

useful for both hydrophilic/phobic drugs

protection of other tissues until drug released

size and charge can be altered

Term
What are some disadvantages of liposomes for parenteral delivery?
Definition

drug release can be slow

they are destroyed by cells of the RES

Term
How are stealth liposomes better than regular liposomes?
Definition

They are Pegulated and not detected by the RES

They have longer circulation times

Term

What is PEGylation?

How is the helpful?

Definition

attaching PED molecules to proteinss

increases half-life and circulation times

Term

What are microspheres?

What effect do they have drug release and compliance?

Stability?

Routes of administration?

 

Definition

drug coated with polymers

 

sustained drug release and increase compliance

 

increase stability

 

Injection or inhalation

Term

T/F (microspheres)

 

a) they are too large for targeting (subQ)

b) release is zero order

c) way to eliminate toxicty

Definition

a) TRUE

b) FALSE rarely 0 order

c) FALSE may be toxic due to dose dumping

Term

T/F (implants)

 

a) pts may have an immune response at the implant surface

b) they have higher variability than controlled release injectables

c) increased efficacy and decreased side effects due to local delivery

Definition

a) TRUE

b) FALSE lower variability

 

c) TRUE

Term
What are the 2 types of implantable devices?
Definition

Reservoir (capsule)

 

Matrix (tablet)

Term
What is biotechnology?
Definition
any technique that uses living organisms for the production or modification of products
Term

Term

 

a) proteins produced by B lymphocytes in response to antigens

 

b) ATB from the culture of a single ancestral B cell

 

c) ATB obtained  from the blood of an immunized animal

 

Definition

 

a) Antibody

 

b) monoclonal ATB

 

c) polyclonal ATB

Term

T/F

 

Recombinant DNA technology can prepare human proteins from nonhuman cells

Definition
TRUE
Term

TERM

 

exogenous genetic material transferred into somatic cells to correct gene defects

Definition
Gene Therapy
Term
What is used to block synthesis of unwanted proteins such as VEGF in cancer?
Definition
antisense nucleotide sequence
Term

TERM

 

screening polypeptides that can mimic larger proteins

Definition
Peptide technology
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