Term
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Definition
using Phosphotidyl choline plus cholesterol make a rigid spherical bilayer.
Phosphtidyl choline plus surfactant make an elastic liposome |
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Term
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Definition
Is elastic
pass thru filter easier
smaller
increase release rate
less stable |
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Term
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Definition
rigid spherical liposome
Large than surfactant
lipid bilayer
more stable |
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Term
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Definition
| measures particle stability |
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Term
| Salt (co-ions) added to phospholipid |
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Definition
| can enhance drug loading, ion charge interaction with cell for drug release |
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Term
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Definition
biocompatible because of phospholipid
both hydrophobic and hydrophilic
protect drug
reduce toxicity
prolong half life
use passive and active targeting |
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Term
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Definition
stability problems (lipid stability and drug leakage)
clearance by MPS
low drug loading
poor control of release
large variation in size |
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Term
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Definition
PEG-Lytaled liposome is hydrophilic to increase MRT to prolong in circulation
decrease macrophage recognition |
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Term
| liposome shape for syringe??? |
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Definition
spherical and smooth shape
sml surface area increases drug release |
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Term
| Nanoparticles via coacervation |
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Definition
uses Dextran sulphate -ve
chitosan +ve
opposite charges increase mechanical strength
safer for water soluble drugs
acetic acid is the solvent therefore stable |
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Term
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Definition
Charge ratio between DS:CS
size: effected by polymer concentration
increased viscosity by increased concentration
Drug targeting via homing device on surface |
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Term
| Nanoparticle via evaporation |
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Definition
Adv: hydrophobic polymers and hydrophilic drugs
Disadv: use organic solvent
ultrasonic probe can degrade drug and alter particle size (short time use only) |
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Term
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Definition
polymer (DL-lactide)
Dichloromethane |
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Term
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Definition
water
poly-vinyl alcohol (stabiliser) |
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Term
| Microcapules via spray drying |
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Definition
for hydrophilic and phobic
not for heat sensitive drugs
can trap salt of the drug
can make suspension or emulsion
Solvent is water so polymer must be soluble
Glutaraldehyde is a cross linking agent to albumin to increase stability to make shell hard to control release |
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