Term
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Definition
inhibit bacterial cell wall synthesis by binding to one or more penicillin-binding (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. |
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Term
| Do cephs exhibit concentration dependent or time dependent killing? |
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Definition
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Term
| Name the first generation cephs |
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Definition
Cefadroxil (Duricef - NIA)
Cefazolin (Ancef, Kefzol)
Cephalexin (Keflex) |
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Term
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Definition
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Term
| Brand name for Cephalexin |
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Definition
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Term
| Second generation Cepalosporins |
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Definition
Cefactor (Raniclor)
Cefotetan (Cefotan - N/A)
Cefoxitin (Meloxin)
Cefprozil (Cefzil - N/A)
Cefuroxime (Ceftin, Zinacef)
Cefamandole (Mandol - N/A)
Loracarbef (Lorabid - N/A)
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Term
| Brand name for Cefprozil and Cefuroxime |
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Definition
Cefprozil (Cefzil - N/A)
Cefuroxime (Ceftin, Zinacef)
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Term
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Definition
Cefdinir (Onicef)
Cefditoren (Spectracef)
Cefixime (Suprax)
Cefotaxime (Claforan)
Cefpodoxime (Vantin)
Ceftazidime (Fortaz, Tazicef)
Ceftibuten (Cedax)
Ceftriaxone (Rocephin)
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Term
| brand name for Cefdinir, Cefixime, and Ceftriaxone |
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Definition
Cefdinir (Onicef)
Cefixime (Suprax)
Ceftriaxone (Rocephin) |
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Term
| Name fourth generation Cephs? |
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Definition
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Term
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Definition
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Term
| Typical dosing for Cefepime |
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Definition
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Term
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Definition
| Ceftaroline fosmil (Teflaro) |
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Term
| Brand name for Ceftaroline fosamil |
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Definition
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Term
| Typical dosing for Ceftaroline fosamil |
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Definition
| 200 - 600 mg Q12 - IV only |
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Term
| What kind of activity does first generation Cephs have? |
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Definition
| Better gram (+) activity than gram (-) activity. |
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Term
| Describe the activity of second generation Cephs |
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Definition
Better gram (-) activity compared to first generation with similar gram (+) activity
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Term
| Describe activity for third generation Cephs? |
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Definition
Better gram (-) activity compared to second generation and less gram (+) activity copmared to second generation |
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Term
| Describe activity of fourth generation Cephs? |
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Definition
Best gram (-) activity and gram (+) activity similar to first generation |
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Term
| Describe activity of fifth generation Cephs? |
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Definition
Covers MRSA and gram (+), some gram (-) |
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Term
| Name a serious side effect of Cephs? |
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Definition
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Term
| Can you use Cephs in those with PCN allergy? |
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Definition
Cross sensitivity with PCN is approximately 10%. So, no. But keep in mind that this (10%) is a rumor. In reality, the corss sensitiviy is 1-3%. Literature supports prescribing Cephs for those allergic to PCNs. But for the NAPLEX, answer no (lol). |
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Term
| Pregnancy category of Cephs |
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Definition
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Term
| Reduce dose in those with renal impairment in all Cephs except for which ones? |
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Definition
Cefoperazone (Cefobid) and Ceftriaxone (Rocephin) |
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Term
| Which Cephs lead to disulfiram-like reaction? |
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Definition
Cefamandole (Mandol), Cefmetazole, and Cefotetan (Cefotan - N/A) |
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Term
Uricosuric agents (probenecid and allopurinol) can increase levels of cephalosporins by interfering with excretion. |
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Definition
| This is not a question. Just a statement. |
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Term
| What is a disulfuram interaction? |
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Definition
Disulfuram is a drug used to treat those with alcohol dependence. Disulfuram basically gives a giant hangover directly after ingesting alcohol. So, Disulfuram like reactions aren't good in those not being treated for alcohol dependence.
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Term
| How do Cephs effect oral contraceptives. |
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Definition
May decrease effectiveness of oral contraceptives - check package insert for individual drug.
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