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Cephalosporins
Generation, spectrum, common uses
18
Other
Professional
01/27/2010
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Term
cephalothin
 Definition
1st gen
Term
cefazolin
 Definition
1st gen
Term
cephalexin
 Definition
(Keflex)
1st gen
Term
cefadroxil
 Definition
1st gen
Term
cefuroxime
 Definition
2nd gen
Term
cefaclor
 Definition
2nd gen
Term
cefprozil
 Definition
2nd gen
Term
cefoxitin
 Definition
cephamycin

better activity for B. fragilis
Term
cefotaxime
 Definition
3rd gen
Term
ceftriaxone
 Definition
- 3rd gen
- t1/2 = 8.5 hours!
Term
cefixime
 Definition
- 3rd gen
- gonorrhea - 400mg stat
Term
ceftazidime
 Definition
- 3rd gen
- antipseudomonal
Term
cefepime
 Definition
- 4th gen
Term
cefpirome
 Definition
- 4th gen
Term
ceftabirole medocaril
 Definition
5th gen
Term
1st generation cephalosporins - coverage
 Definition
Good for Staph
Moderate for Strep
Use for skin infex
Term
cephalosporine MOA
 Definition
- beta-lactam - binds bacterial PBPs, cell wall disruption

- time-dependant killing
Term
Never use a cephalosporin for
 Definition
Enterococci
Listeria
B. fragilis (cephamycin OK)
atypicals/intracellulars
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