Term
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Definition
ANCEF
1ST GEN
BILE DISTRIBUTION
80% PPB
HAVE METHYLTHIOTETRAZOLE STRUCTURE (CH3ST4AZOLE)--CAUSES INCREASED BLEEDING TENDENCY
IND: SSSI |
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Term
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Definition
DURICEF
ONLY 1ST GEN THAT IS LA
ORAL ADMIN |
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Term
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Definition
CEFADYL
1ST GEN; SA
AE: PAIN AT THE SITE OF INJECTION
AVAILABLE IV AND IM--PREFER IV BC IM IS PAINFUL |
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Term
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Definition
KEFLIN
1ST GEN; SA
Q4H PARENTRAL ADMIN
AE: PAIN AT THE SITE OF INJECTION
AVAILABLE IV AND IM--PREFER IV BC IM IS PAINFUL |
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Term
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Definition
| VELOSEF; ANSPOR
1ST GEN
ORAL ADMIN
BONE DISTRIBUTION |
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Definition
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Term
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Definition
CECLOR
2ND GEN--retains properties of 1st gen
ORAL ADMIN
Ind: UPPER RTI: OTITIS MEDIA |
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Term
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Definition
MANDOL
2ND GEN; SA
BONE DISTRIBUTION
HAVE METHYLTHIOTETRAZOLE STRUCTURE (CH3ST4AZOLE)--CAUSES INCREASED BLEEDING TENDENCY
AE: Alcohol intolerance--Disulfuram like effects |
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Term
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Definition
ZINACEF
2ND GEN; IA
INJECTABLE
BONE & CNS DISTRIBUTION
SIMILAR SPEC AS CEPHAMYCINS BUT NOT CEPHAMYCINS B/C PRODUCED BY CEPHALOSPORIUM ACREMONIUM |
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Term
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Definition
CEFTIN
2ND GEN; IA
ORAL ADMIN
CNS DISTRIBUTION
SIMILAR SPEC AS CEPHAMYCINS BUT NOT CEPHAMYCINS B/C PRODUCED BY CEPHALOSPORIUM ACREMONIUM
Ind: UPPER RTI: OTITIS MEDIA |
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Term
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Definition
MEFOXIN
2ND GEN; SA (STRUCTURAL CLASS: CEPHAMYCINS)
PRODUCED BY STREPTOMYCES LACTAMDURANS
IND: SSSI--often used to manage SSSI during colerectal surgery; Human bite |
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Term
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Definition
CEFOTAN
2ND GEN; LA (STRUCTURAL CLASS: CEPHAMYCINS)
PRODUCED BY STREPTOMYCES LACTAMDURANS
> 80% PPB
HAVE METHYLTHIOTETRAZOLE STRUCTURE (CH3ST4AZOLE)--CAUSES INCREASED BLEEDING TENDENCY
AE: Alcohol intolerance--Disulfuram like effects
IND: Human Bite |
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Term
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Definition
ZEFAZONE
2ND GEN; LA (STRUCTURAL CLASS: CEPHAMYCINS)
PRODUCED BY STREPTOMYCES LACTAMDURANS
AE: Alcohol intolerance--Disulfuram like effects
IND: Human bite |
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Term
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Definition
MONOCID
2ND GEN; LA
LA admin on QD basis
BONE DISTRIBUTION
> 80% PPB
HAVE METHYLTHIOTETRAZOLE STRUCTURE (CH3ST4AZOLE)--CAUSES INCREASED BLEEDING TENDENCY |
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Term
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Definition
LORABID
2ND GEN (STRUCTURAL CLASS: CARBACEPHEM)
ORAL ADMIN |
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Term
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Definition
CEFZIL
2ND GEN--also properties of 3rd GEN
ORAL ADMIN |
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Term
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Definition
PRECEF
2ND GEN
BONE & BILE DISTRIBUTION
> 80% PPB
HAVE METHYLTHIOTETRAZOLE STRUCTURE (CH3ST4AZOLE)--CAUSES INCREASED BLEEDING TENDENCY |
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Term
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Definition
CEFOBID
3RD GEN; LA
BONE & BILE DISTRIBUTION
distribution into the bile is a major factor in the pharmacokinetics of Cefobid--major route of excretion is BILE--concern for pts with hepatic dysfunction
LA--GIVEN 2X DAY
> 80% PPB
HAVE METHYLTHIOTETRAZOLE STRUCTURE (CH3ST4AZOLE)--CAUSES INCREASED BLEEDING TENDENCY
AE: Alcohol intolerance--Disulfuram like effects |
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Term
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Definition
CLAFORAN
3RD GEN; SA q4h
CNS DISTRIBUTION
IND: LOWER RTI (e.g Bronchitis, ABECB, CAP); SSSI--often used to manage SSSI during colerectal surgery; HACEK-induced endocarditis; Lyme disease caused by Borrelia burgdorferi; empirical mgmt of meningitis in child or infant not caused by pseudomonas aeruginosa; STDs (gonorrhea and chancroid); Cat bite fever (b/c you often have Pasteurella involved) |
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Term
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Definition
CEFIZOX
3RD GEN
BONE & CNS DISTRIBUTION |
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Term
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Definition
MOXAM
3RD GEN (STRUCURAL CLASS: OXACEPHEM)
CNS DISTRIBUTION
HAVE METHYLTHIOTETRAZOLE STRUCTURE (CH3ST4AZOLE)--CAUSES INCREASED BLEEDING TENDENCY--critical for MOxam b/c it has been known to cause death b/c of hyperprothombinemia that it produces which leads to bleeding
AE: Alcohol intolerance--Disulfuram like effects |
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Term
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Definition
ROCEPHIN
3RD GEN; LA q24h
BILE & CNS DISTRIBUTION
> 80% PPB
IND: LOWER RTI (e.g Bronchitis, ABECB, CAP); HACEK-induced endocarditis; Lyme disease caused by Borrelia burgdorferi; empirical mgmt of meningitis in child or infant not caused by pseudomonas aeruginosa; STDs (gonorrhea and chancroid)--Rocephin is DOC for the inital mgmt of gonorrhea (200mg IM ONCE) |
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Term
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Definition
FORTAZ
3RD GEN
BONE DISTRIBUTION
GIVEN PARENTRALLY
among all cephalosporins FORTAZ is the best one for the management of pseudomonas aeruginosa infns (e.g meningitis)--usually given concurrently with aminoglycosides for the mgmt of serious meningitis |
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Term
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Definition
3RD GEN
NOT VERY OFTEN USED |
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Term
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Definition
SPECTRACEF
3RD GEN; LA
PRODRUG: b/c it has to undergo hydrolysis by esterases before the active moiety is released
Ind:limited to the respiratory tract and the skin--mainly used for ABECB, CAP, & SSSI
Admin ORALLY 200MG PO BID
> 80% PPB
HAVE METHYLTHIOTETRAZOLE STRUCTURE (CH3ST4AZOLE)--CAUSES INCREASED BLEEDING TENDENCY |
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Term
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Definition
VANTIN
3RD GEN; LA
ORAL ADMIN |
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Term
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Definition
OMNICEF
Mostly used 3RD GEN; LA
ORAL ADMIN
Ind: UPPER RTI: OTITIS MEDIA |
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Term
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Definition
CEDAX
3RD GEN; LA
ORAL ADMIN |
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Term
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Definition
SUPRAX
3RD GEN
ORAL ADMIN
Ind: UPPER RTI: OTITIS MEDIA |
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Term
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Definition
MAXIPIME
ONLY 4TH GEN THAT IS CURRENTLY USED CLINICALLY
CNS DISTRIBUTION
100% RENAL EXCRETION
IND: EMPIRICAL MGMT OF NOSOCOMIAL INFN. PARTICULARY WHEN THESE INFN. ARE CAUSED BY CITROBACTER FREUNDII, ENTEROBACTER AEROGENES, OR SERRATIA MARCESCENS SPS. |
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Term
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Definition
CEFROM
4TH GEN-- COMING OUT SOON |
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Definition
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Definition
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Term
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Definition
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Term
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Definition
4TH GEN IN TRIAL
ALREADy OF CLINICAL SIGNIFICANCE B/C IT IS A PRECURSOR TO THE 5TH GEN CEFTAROLINE(TEFLARO) |
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Term
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Definition
ZEVLERA
5TH GEN
INTERACTS WITH PBP 2a (most other cephs interact with PBP 1 & 3)
used for the mgmt of MRSA infns especially when it is causing SSSI
also used for the mgmt of RTI especially when caused by Strep. pneumoniae, or even when caused by Pseudomonas aeruginosa |
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Term
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Definition
TEFLARO
5TH GEN
INTERACTS WITH PBP 2a (most other cephs interact with PBP 1 & 3)
ONLY ADMIN IV
400-600MG Q12H X 5D for mgmt of RTI like CAP (community acquired pneumonia) and ABECB (acute bacterial exacerbation of chronic bronchitis)
400-600MG Q12H X 10D for mgmt of SSSI particularly when caused by Staph (including MRSA), Strep, E.coli, & Klebsiella
very effective when infecting organism is either Strep. pneumoniae, Staph. aureus (including MRSA), E. coli, Klebsiella pneumoniae, & Haemophilus influenza |
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