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Central Nervous System Infections
Overview
56
Art History
10th Grade
03/24/2014

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Cards

Term
WBC Normal values (cells/mm3)
Definition
<5
Term
WBC Bacterial values (cells/mm3)
Definition
1,000-5,000 increase
Term
Cerebral Spinal Fluid Normal Differential %
Definition
>90
Term
Cerebral Spinal FLuid Bacterial Differential %
Definition
> or equal to 80 polymorphonuclear neutrophils (PMNs)
Term
Protein (mg/dL) Normal value
Definition
< 50
Term
Protein (mg/dL) Bacterial values
Definition
100-500 - increase
Term
Glucose (mg/dL) Normal serum value
Definition
50-60%
Term
Glucose (mg/dL) Bacterial value
Definition
40% decrease (a nutrient) (<60% serum value)
Term
1 month - 4 years old most likely organism for bacterial meningitis
Definition
S. Pneumoniae, N meningiditis, H. influenzae
Term
1 month- 4 years old Empirical Therapy for Bacterial Meningitis
Definition
Vancomycin and cefotaxime or ceftriaxone
Term
Newborn- 1 month most likely organism for bacterial meningitis
Definition
Group B Streptococcus, Gram-negative enterics, Listeria monocytogenes
Term
Newborn-1 month empirical therapy for bacterial meningitis
Definition
Ampicillin plus cefotaxime or ceftriaxone or aminoglycoside
Term
5-29 years most likely organism for bacterial meningitis
Definition
N. meningiditis, S. pneumoniae, H. influenzae
Term
5-29 years old empirical therapy for bacterial meningitis
Definition
Vancomycin and cefotaxime or ceftriaxone
Term
30-60 years most likely organism for bacterial meningitis
Definition
S. pneumoniae, N. meningiditis
Term
30-60 years empirical therapy for bacterial meningitis
Definition
Vancomycin and cefotaxime or ceftriaxone
Term
> 60 years old most likely organism for bacterial meningitis
Definition
S. pneumoniae, Gram-negative enterics, L. monocytogenes
Term
> 60 years old empirical therapy for bacterial meningitis
Definition
Vancomycin plus ampicillin plus cefotaxime or ceftriaxone
Term
Streptococcus pneumoniae: Penicillin- susceptible (abx 1st choice)
Definition
Penicillin G or ampicillin (A-III)
Term
Streptococcus pneumoniae: Penicillin-intermediate (Abx 1st choice)
Definition
Cefotaxime or ceftriaxone (A-III)
Term
Streptococcus pneumoniae: Penicillin- resistant (Abx 1st choice)
Definition
Vancomycin plus cefotaxime or ceftriaxone (A-III)
Term
Streptococcus pneumoniae: Penicillin-susceptible (alternative antibiotics)
Definition
Cefotaxime (A-III), ceftriaxone (A-III), chloramphenicol (A-III)
Term
Streptococcus pneumoniae: Penicillin-intermediate (alternative antibiotics)
Definition
Cefepime (B-II), meropenem (B-II), moxifloxacin (B-II), linezolid (C-III)
Term
Streptococcus pneumoniae: Penicillin-resistant (alternative antibiotics)
Definition
Cefepime (B-II), meropenem (B-II), moxifloxacin (B-II), linezolid (C-III)
Term
Streptococcus pneumoniae meningitis Txt Duration
Definition
10-14 Days
Term
Group B Streptococcus (abx of first choice)
Definition
penicillin G or ampicillin +/- gentamicin (A-III)
Term
Group B Streptococcus (alternative abx)
Definition
Cefepime (B-III), meropenem (B-III), chloramphenicol (B-III)
Term
Staph aureus Methicillin-susceptible (1st choice abx)
Definition
nafcillin or oxacillin (A-III)
Term
Staph aureus methicillin resistant (1st choice abx)
Definition
vancomycin (A-III)
Term
staph aureus methicillin-susceptible (alternative abx)
Definition
vancomycin (A-iii), meropenem (B-III)
Term
staph aureus methicillin-resistant (alternative abx)
Definition
trimethoprim-sulfamethoxazole (A-III) linezolid (B-III)
Term
staph epidermidis (abx 1st choice)
Definition
vancomycin (A-III)
Term
staph epidermidis (alternative abx)
Definition
LInezolid (B-III)
Term
Listeria monocytogenes (abx 1st choice)
Definition
Penicillin G or ampicillin +/- gentamicin (A-III)
Term
Listeria monocytogenes (alternative abx)
Definition
trimethoprim-sulfamethoxazole (A-III), meropenem (B-III)
Term
Group B Streptococcus meningitis Txt Duration
Definition
14-21 days
Term
Staph aureus meningitis Txt Duration
Definition
14-21 days
Term
Staph epidermidis meningitis Txt Duration
Definition
14-21 days
Term
Listeria monocytogenes meningitis Txt Duration
Definition
> 21 days
Term
Neisseria meningitis = memingococcus Penicillin susceptible- most (abx 1st choice)
Definition
Penicillin G or ampicillin
Term
Neisseria meningitis = memingococcus Penicillin-susceptible-most (alternative abx)
Definition
Cefotaxime, ceftriaxone, chloramphenicol
Term
Neisseria meningitis = memingococcus Penicillin-resistant (abx 1st choice)
Definition
Cefotaxime or ceftriaxone
Term
Neisseria meningitis = memingococcus Penicillin-resistant (alternative abx)
Definition
chloramphenicol, meropenem, fluoroquinolone
Term
Haemophilus influenzae: beta lactamase negative (Abx 1st choice)
Definition
ampicillin
Term
Haemophilus influenzae: beta lactamase negative (abx alternative)
Definition
cefotaxime, ceftriaxone, chloramphenicol, cefepime, fluoroquinolone
Term
Haemophilus influenzae: beta lactamase positive (Abx 1st choice)
Definition
cefotaxime or ceftriaxone
Term
Haemophilus influenzae: beta lactamase positive (abx alternatives)
Definition
cefepime, fluoroquinolone, chloramphenicol
Term
Enterobacteriaceae (1st choice abx)
Definition
cefotaxime or ceftriaxone
Term
Enterobacteriaceae (abx alternatives)
Definition
cefepime, fluoroquinolone, meropenem, aztreonam
Term
Pseudomonas aeruginose (1st choice abx)
Definition
cefepime or ceftazidime +/- tobramycin
Term
Pseudomonas aeruginose (abx alternative)
Definition
ciprofloxacin, meropenem, piperacillin plus tobramycin, colistin sulfomethate, aztreonam
Term
Neisseria meningitis txt duration
Definition
7 days
Term
haemophilus influenzae txt duration
Definition
7 days
Term
enterobacteriaceae txt duration
Definition
21 days
Term
pseudomonas aeruginosa txt duration
Definition
21 days
Term
most potent steroid- good for decreasing cerebral swelling- lessened permanent mental retardation in pts with meningitis due to swelling back in the days; may not be as beneficial anymore, it is now used for only the first 24 hours
Definition
Dexamethasone
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