Term
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Definition
| Causes misreading of the genetic code in prokaryotes. Interferes with initiation. |
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Term
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Definition
| Inhibits binding of aminoacyl-tRNA to A-site |
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Term
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Definition
| Inhibits peptidyl transferase activity on ribosomes |
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Term
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Definition
| Binds to the 50S subunit and inhibits translocation |
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Term
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Definition
Resembles aminoacyl-tRNA and binds to A-site which causes premature release of polypeptide chain
(prokaryotes and eukaryotes) |
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Term
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Definition
| Inhibits peptidyl transferase activity of the 60S ribosome (Eukaryotes) |
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Term
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Definition
| Inhibits eEF-2 and prevents translocation |
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Term
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Definition
| Inactivates 60S subunit of ribosome |
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Term
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Definition
| Vitamin B1, converted to thiamine pyrophosphate TPP, with pyruvate dehydrogenase it cleaves a C-C bond in pyruvate to create acetaldehyde. |
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Term
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Definition
| Vitamin B2, coenzyme for FAD and FMN |
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Term
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Definition
| Important for coenzymes NAD and NADP. Required in large amounts |
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Term
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Definition
| Forms Coenzyme A which transports acetyl groups from one substrate to another |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| Acts as a cofactor for enzymes that add carboxyl groups to substrates. |
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Term
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Definition
| Most complex vitamin, complexed with Cobalt. It is required for methyl transfer |
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Term
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Definition
| Important target for antibiotics and anticancer. Important for single carbon unit reactions and formation of nucleotides. |
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Term
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Definition
| Vitamin C. Protects cells from reactive oxygen species as an antioxidant. |
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Term
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Definition
| fat soluble vitamin. Inportant in the prothrombin pathway. Anticlotting drugs work by blocking the enzyme that reduces Vitamin K. |
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Term
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Definition
| Anticancer drug inhibits human DHFR and since tetrahydrofolate is required for the production of nucleic acid bases-cancer cell production is blocked. |
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Term
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Definition
| Trimethoprim works on bacterial DHFR and is an antibacterial agent |
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