Term
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Definition
| Destruction & elimination of intracellular or cell-associated Ag |
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Term
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Definition
| Majority of Tc cells are CD8^+ T cells( small subset are CD4^+ T cells) |
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Term
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Definition
| Ag peptide:MHC I complex via TCR |
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Term
| The ultimate terminally differentiated effector cell of the T cell-mediated immune response is? |
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Definition
| The CYTOTOXIC T Lymphocyte (CTL), which is capable of directly killing target cells. Memory Tc cells/CTL-Ps are also generated |
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Term
| ________ are unable to kill cells & so are also referred to as CTL precursor or CTL-P. |
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Definition
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Term
| Type 1 T helper(Th1) cells: |
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Definition
| Th cells are required for maximal activation of naive Tc cells interacting w/activated Dendritic cells (APCs) but not virus-infected DCs |
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Term
| In general, memory CTL-Ps Do NOT require Th cell help because they can? |
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Definition
| Locally produce sufficient IL-2 & express IL-2R once activated |
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Term
| Th1 cells function as effector cells secreting cytokines such as? |
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Definition
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Term
| Ag-Presenting Cells(APC):_________ are important APCs for Th cells & Tc cells(CTL-Ps) in the CMI response...presenting Ag-peptide w/MHCII & MHCI, respectively |
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Definition
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Term
| Other "Ag-presenting cells" include the ultimate target cells of the CMI response...? |
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Definition
| "non-self" cell, tumor cell or virus-infected cell...presenting Ag-peptide w/MHCI |
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Term
| Th cells are________ & Tc cells are________. |
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Definition
1)MHCII-restricted
2)MHCI-restricted |
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Term
| Ag Stimulating Tc CMI Response: |
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Definition
| Ag stimulating CMI responses are cell associated Ag because peptide:MHC on surface of cell |
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Term
| Graft rejection most strongly targeted difference at MHCI & to lesser degree, MHCII on foreignor non-self cells surfaces referred to as? |
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Definition
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Term
| Early in the MLR lymphocyte proliferation is the major event indicating that the 2 lymphocyte population are? |
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Definition
| Allogenic/ differ at the MHCII genotypes-Why?...AlloMHC II dependent |
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Term
| Later in the MLR cytotoxicty becomes the MAJOR event indicating tht the 2 lymphocyte population are? |
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Definition
| Allogenic/differ at the MHC I genotype-WHy? AlloMHC I-dependent |
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Term
| Alloreactivity can also result from? |
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Definition
| the release of alloMHC Ag as foreign cells die, which can then be taken up, processed and presented by dendritic cells to the appropriate T cells---GRAFT REJECTION |
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Term
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Definition
| A major "natural" function of Tc cells is to target Ag associated with intracellular pathogen |
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Term
| Abnormal self or tumor Ag: |
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Definition
| can be processed and presented w/MHC I on tumor cell surfaces and shed to be taken up, processed and presented by APCs with MHCII leading to stimulation of CTL-P & Th cells---Tumor rejection |
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Term
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Definition
| Generation of CTL from naive CTL-P...also generation of Th cells from CD4 Th cells |
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Term
| Sensitization phase also generates...? |
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Definition
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Term
| IFN-gamma from Th1 cells & CTLs increase? |
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Definition
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Term
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Definition
| CTL mediated lysis of target cell; Cytokine secretion by both Th1 cell & activated CTL-P/CTL |
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Term
| Cytotoxicity requires 2nd binding of CTL to same Ag:MHC I on target cell to form a...? |
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Definition
| CTL:target cell conjugate, which exocytosis of granule contents leading tot target cell apoptosis |
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Term
| Release of _____&______ leads to formation of pores/channels in the target cell membrane that allow GRANZYMES to enter target cell. |
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Definition
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Term
| Granzymes & Fas ligand binding to Fas receptor... |
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Definition
| triggers apoptotic pathways leading to target cell death |
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Term
| Directional release of granular components protect___from the actions of these factors allowing___ to dissociate from the target cell & move on to another target cell. |
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Definition
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Term
| Delayed-type Hypersensitivity(DTH) Response: 1st observed by? |
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Definition
| Robert Koch--tuberculin reation |
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Term
| DTH reflects a____ host immune response. |
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Definition
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Term
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Definition
| generate activated macrophage in order to kill the intracellular pathogen |
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Term
| Cells involved in DTH response: T cells |
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Definition
| Primarily CD4 Tcells-Th1 cells; sometimes CD8 T cells |
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Term
| Production of CYTOKINES CD40L & CHEMOKINES support their own______&_______&________,_______and ___________ Macs and PMNs. |
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Definition
proliferation
differentiation
activate
attract
replenish |
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Term
| APCS are primarily _____ & ______ cells. |
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Definition
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Term
| APCs activated Th cells...? |
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Definition
| proliferation and differentiation into effector(Th1) cells and memory Th cells--- Sensitization |
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Term
| Effector cells are Th cells that produce_____ +CD40L & chemokines that activates and recruits______. |
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Definition
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Term
| Activated(angry) Macrophage: |
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Definition
| Activated by cytokines + CD40L produced by Th1 cell show enhanced phagocytic activity |
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Term
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Definition
| increase killing of intracellular parasites and increase presentation of associated Ag-peptide |
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