Term
| Most endocytosis is not ?, but occurs in very efficient Receptor Mediated endocytosis pathway |
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Definition
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Term
| In low density lipoprotein (LDL)what is digested what is recycled |
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Definition
ligand is digested in lysosome
receptor recycled |
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Term
| What is recycled or digested in Transferrin? |
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Definition
| ligand and receptor are both RECYCLED |
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Term
| What is digested or recycled in Epidermal Growth Factor (EGF) |
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Definition
| Ligand and receptor are both digested in lysosome |
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Term
| in EGF transfer to lysosome what helps keep receptor in endosome? |
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Definition
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Term
| Transcytosis is seen in what? |
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Definition
| globulins (definitely immunoglobulins like IgA) |
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Term
| Early endosomes mature into what and then what? |
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Definition
| mature into late endosomes/multivesicular bodies (MVBs) and then lysosomes |
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Term
| Digestive enzymes are delivered to endosomes from the ? in clathrin coated vesicles |
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Definition
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Term
| what contain undigested residues and are very dark with light lipid patches. they accumulate in long-lived cells like heart and brain |
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Definition
| Lipofuscin granules/residual bodies |
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Term
| Neurons can have brown ? around the nucleus |
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Definition
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Term
Materials taken up in what may go to a number of locations including endosomes ER transcytosis
Can do signaling not just for digestion? |
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Definition
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Term
| Digestion of cellular organelles is called? |
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Definition
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Term
What disease is due to a defective glucocerebrosidase?
Mild form = spleen macrophages can not completely digest aged RBC's
ERT successful! Yay! |
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Definition
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Term
What disease is due to a defective N-acetyl-hexosaminidase? Due to accum of undigested glycolipids, particularly in neurons.
ERT unsuccessful
blood-brain barrier makes access difficult |
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Definition
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Term
| In what disease are lysosoaml enzymes synthesized but not phosphorylated and are delivered to the secretory pathway instead of to late endosomes. Fatal in childhood |
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Definition
I-Cell Disease
*not all cells are affected so there is another way lysosomal enzymes are directed to endosomes |
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Term
| What are the 3 types of ubiquitin-tagged cytoplasmic and nuclear proteins that are destroyed? |
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Definition
| Unneeded, short lived, abnormal/misfolded proteins |
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Term
What are generally more toxic to rapidly dividing cells (cancer cells)
due to proteasome degradation inactivating the cyclin-Cdk complex |
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Definition
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Term
| What contain a variety of oxidative enzymes including catalase and can oxidize long chain fatty acids? |
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Definition
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Term
| What are required for plasmalogen synthesis (lipid synth) |
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Definition
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Term
| where are peroxisomal enzymes synthesizes |
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Definition
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Term
What is due to a mutation in one of the peroxisomal membrane transporters
(few enzymes are transported into the peroxisome) |
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Definition
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Term
| What is caused by damage and leads to swelling and rupture? Inflammation develops. |
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Definition
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Term
| External ? ligands bind to ? (death) receptors on the cell surface to activate caspase cascade. |
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Definition
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Term
Internally release of ? activates caspase cascade?
What is an anti-apoptotic protein which inhibits release of cytochrome C from mitochondria? |
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Definition
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Term
| Cells with DNA damage are monitored by ? which triggers either DNA repair or apoptosis. |
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Definition
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Term
| Mutan proteins may be digested even though ? What is mutated in cystic fibrosis and then destroyed by proteasomes |
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Definition
functional
mutated chloride channel protein (CFTR) |
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