Term
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Definition
| Binds sister chromatids during mitosis thru G2 |
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Term
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Definition
| large protein complexes that play a central role in chromosome assembly and segregation in eukaryotic cells |
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Term
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Definition
| Generate microtubule instability |
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Term
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Definition
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Term
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Definition
| Attach sister chromatids to the spindle |
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Term
| 3 classes of microtubules |
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Definition
1)Kinetochore microtubules attach each
chromosome to the spindle pole
2)Interpolar
microtubules hold the two halves
of the spindle together
3)Interpolar microtubules hold the two halves of the spindle together |
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Term
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Definition
| 10% of DNA packaged tightly in periphery of nucleus |
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Term
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Definition
| mediate cell adhesion at adherin junction |
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Term
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Definition
| Protein components of chromatin. They act as spools around which DNA winds, and they play a role in gene regulation. Without histones, the unwound DNA in chromosomes would be very long |
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Term
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Definition
| Subunit of chromatin composed of a short length of DNA wrapped around a core of histone proteins |
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Term
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Definition
| spherical sub-organelles found in the nucleus of proliferative cells like tumor cells, or metabolically active cells like neurons (sites where snRNPs undergo final modification) |
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Term
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Definition
| Bind, package DNA into tight coils |
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Term
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Definition
4 subunits:
Lumenal-contain transmembrane protein
that anchor pore to nuc. memb.
Column- forms wall
Ring- form cystolic/nuclear faces
Annular-extends spokes |
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Term
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Definition
| Nuclear localization signals- targeting of a protein to the nucleus req's a signal |
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Term
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Definition
| cell-cell anchoring,channel forming, cell-matrix |
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Term
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Definition
| a cell structure specialized for cell-to-cell adhesion. A type of junctional complex, they are localized spot-like adhesions randomly arranged on the lateral sides of plasma membranes. |
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Term
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Definition
| desmoglein, desmocollin, desmoplakin |
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Term
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Definition
| a family of proteins that are the most important components of the tight junctions, where they establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. |
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Term
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Definition
| integral plasma-membrane protein located specifically at tight junctions |
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Term
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Definition
| a non-sulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is one of the chief components of the extracellular matrix, contributes significantly to cell proliferation and migration, and may also be involved in the progression of some malignant tumors. |
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Term
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Definition
| a normal gene that can become an oncogene due to mutations or increased expression (gain of function, dominant) |
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Term
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Definition
| a normal gene that can become an oncogene due to mutations or increased expression |
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Term
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Definition
| a layer of extracellular matrix on which epithelium sits and which is secreted by the epithelial cells. |
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Term
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Definition
| Initiates sister chromatid separation |
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Term
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Definition
| H2A,H2B,H3,H4 (small basic highly conserved proteins) |
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