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Cell bio exam mid Qs
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39
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1st Grade
12/07/2010

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Term

The series of invaginated membrane sheets in a mitochondrion are called

 

Definition
cristae
Term
The eight histone core of a nuclesome is compirsed of dimers of?
Definition
H2A, H2B, H3, and H4
Term
The tissue of origin of a metastasized tumor cell can be determined based on its
Definition
intermediate filaments
Term

Which statement is correct

 

a) Facultative heterochromatin is never transcribed

b) Constitutive heterochromatin is transcribed mroe often

c)Euchromatin is found in areas with low transcription activity

d) Facultative heterochromatin can be specifically inactivated

e) chromatin is never transcribed

Definition
d) facultative heterochromatin can be specifically inactivated
Term
The spindle assembly checkpoint (SAC) occurs between which meitotic phases?
Definition
metaphase and anaphase
Term
which drug binds to the plus ends of actin microfilaments, preventing the addition of new G-actin monomers and thereby causing actin microfilament depolymerization?
Definition
cytochalasin
Term

Which of the following statements regardin microtubules is INCORRECT?

 

a) Growth and shrinkage depends on the rates of tubulin heterodimer addition versus GTP hydrolysis

b) New tubulin heterodimers are added to both the minus and plus ends of the microtuble

c) Microtubule catastrophe occurs when there is a decrease in the concentration of free tubulin heterodimers.

d)GTP hydrolysis is requied for polymerization

e) Simultaneous assembly can occur at one end and dissembly at the other end of a microtubule.

Definition
d) GTP hydrolysis is required for polymerization
Term

The following are present in outer membranes of both mitochondria and gram negative bacteria:

a) porins

b)mitopopres

c) bacteriophores

d) nucleoporins

e) chromophores

Definition
a) porins
Term
how does the cell plate develop in a dividing plant cell?
Definition
centrifugally
Term
Which  molecule is composed of two long polypeptides with several globular domains for binding other molecules?
Definition
fibronectin
Term
Which type of proteins are responsible for orgainzing microfilmments into three-dimensional networks in animal cell?
Definition
filamin
Term
Scurvy is the result of defects in which molecule?
Definition
collagen
Term

Which ofthe following statements regarding the components of the the cytoskelton is incorrect?

 

a) various motor proteins bind to microtubules or microfilaments

b)the cytoskeleton positions membrane-bound organelles with the cytosol

c) all three cytoskeleton elements are polar

d)all three cytskeleton elements play a role in maintaining cell struture

e) all three cytoskeleton elements are multimeric proteins composed of many repeats of a basic subunit

Definition
c) all three cytoseleton elments are polar
Term
The meshwork of proteins containing phenylaline-glucine (FG) repeat domains is found in:
Definition
the nuclear pore
Term

which statement is true?

 

a) The nucleous is not compartmentizliaed further

b) different chromosomes can have specific locations within a nucleous

c) the nucleous is always round and in the centre of the cell

d) The nucleus always has one nucleous

e) The nuclear envelope remains intact htroughout the cell cycle

Definition
b) different chromosomes can have specific loactions with a nucleus
Term

which of the following represents progessivley higher levels of dna packaging?

 

a)DNA double helix-nucleosome-30nm gibre

b) DNA double helix- 30nm fibre- nucleosome

c) Nucleosome - DNA double helix - 30 nm fibre

d) 30 nm fibre- nucleosome - DNA double helix

e) the order does nto matter

Definition
a) DNA double helix - nucleosome - 30 nm fibre
Term
Which event requires Ran - GTP mediation during nuclear protein import?
Definition
Dissociation of importin-cargo protein complex
Term
In 'search and capture' scenario, microtubules search for what portion on a chromatid?
Definition
kinetochore
Term
which activitey is involeved in cyclin-dependt kinase regulation?
Definition
cyclin binding
Term
The inner-most layer of the nuclear envelope is lined with
Definition
lamins
Term
which proteins helps form tissues in animals by interacting directyl with various components in the extracellular matrix?
Definition
integrins
Term
During late anaphase interpolar microtubles exhibit:
Definition
net elongation
Term

Which of the following statements regarding gap junctions is correct?

 

a) Gap junctions are composed primarly of claudins

b) Gap junctions function primarly to allow adjacent cells in a tissue to cooperate metabolically

c) Gap junctinos encricle cells

d) Gap junctions primarly prevent the passage of extracellular materials between adjacent cells

e ) Gap junctions link intermediate filaments to form a continuous cytoskeleton network thoughtout a tissue

Definition
b) gap junctions function primarly to allow adjacent cells in a tissue to cooperate metabolically
Term
which sturucture helps to prevent the movement of integral membrane proteins from the lateral to the apical region of an intestinal epithelial cells?
Definition
tight junctions
Term
aneuplodiy refers to?
Definition
an abonormal number of chromosomes
Term
The orientation of what type of plant cell wall molecule is determined by microtubules?
Definition
cellulose microfibirils
Term
name the integral membrane protein that regulates the functino of a tight junction
Definition
claudin
Term
Nuclei of a Calico cat coften shows a dark staingin _____ which indicates thta one of the two ________ is in an inactivate state. the calico cat serves as an example of the presence of ___________ as compared to _________, which remains mostly inactived.
Definition
Nuclei of a Calico cat coften shows a dark staingin Barr body which indicates thta one of the two X-chromosomes is in an inactivate state. the calico cat serves as an example of the presence of facultative heterochromatin as compared to constituve heterochromatin  which remains mostly inactived.
Term
_____ and ______ in the plant cell wall play a similar role to laminin and fibronectin the the animal cell's extracellular matrix
Definition
Extensins  and hemicellulose in the plant cell wall play a similar role to laminin and fibronectin the the animal cell's extracellular matrix
Term
Some proteins can freely diffuse in and out of the nucleos but others require a specific ____________________________ for their _____________________ mediated movemenet into the nucleus.
Definition
Some proteins can freely diffuse in and out of the nucleos but others require a specific nuclear localization signal for their importin mediated movemenet into the nucleus.
Term
_______ is the major protein in hte gap junction
Definition
connexin is the major protein in the gap junction
Term
2 functions of the basal lamina?
Definition

mechaincal support for affected cells

+

Barrier to macromolecular passage

Term
Name the molecular motor protein associated with actin
Definition
myosin
Term
In a mitotic spindle some microtubles known as _________ extend between the centromsoems and the kinetochores while others, known as ______ radiate outward from the centrosome into the space away from the spindle
Definition
In a mitotic spindle some microtubles known as chromosomal microtubules extend between the centromsoems and the kinetochores while others, known as astral micrortubles radiate outward from the centrosome into the space away from the spindle
Term
desribe role of GTPase-activating protein
Definition
hydrolyzes GTP and GDP and thus regulates G-proteins
Term
Describe major role of condensin within the cell
Definition
Binds supercoiled DNA within a chromatid/Compacts chromomes during prophase
Term
Name the microtuble orgainizign center in animal cells
Definition
centrosome
Term
The nucleous uslally contains once or more _________________ along with Gjal bodies, GEMS and dense nuclear ________
Definition
The nucleous uslally contains once or more nucleolus along with Gjal bodies, GEMS and dense nuclear speckles
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