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Cecil Essentials of Medicine chapter 78/87
LECOM 2015 PBL case 174
30
Medical
Post-Graduate
03/19/2012

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Cards

Term
Lab
SF: crystals, high WBC, >80%PMN
Definition
gout
Term
Lab:
SF: high WBC, >90%PMN, culture
Definition
septic arthritis
Term
Lab: noninflammatory SF
Definition
OA
Term
Lab: SF: High WBC, >70% PMN
Definition
RA
Term
Lab:
SF: Moderate WBC, >50% PMN
Definition
Reiter syndrome (reactive arthritis)
Term
Lab:
SF: Low to moderate WBC, ANA +
Definition
SLE
Term
hands and knees
Definition
SLE
Term
axial skeleton, pelvis, sacroiliac joints
Definition
spondyloarthropathy
Term
oligoarticular asymmetrical
Definition
reiter syndrome (reactive arthritis)
Term
symmetrical, small joints
Definition
RA
Term
weight-bearing, hands
Definition
OA
Term
monoarticular or oligoarticular
Definition
gout
Term
podagra, rapid onset of attack, tophi
Definition
gout
Term
fever, chills
Definition
septic arthritis
Term
rheumatoid nodules, extra-articular
Definition
RA
Term
urethritis, conjunctivitis, skin and mucous membranes
Definition
reiter syndrome (reactive arthritis)
Term
uveitis, aortic insufficiency, enthesopathy
Definition
spondyloathropathy
Term
nonerosive joint disease, autoantibodies, multiorgan disease
Definition
SLE
Term
monoarthritis
Definition
septic or crystal induced
Term
pauciarthrits or oligoarthritis (2-4)
Definition
Reiter, psoriatic
Term
polyarthritis (5 or more joints)
Definition
RA, SLE
Term
pencil in cup leisons
Definition
erosive psoriatic arthritis
Term
sacroiliitis
Definition
ankylosing spondylitis
Term
syndesmophytes
Definition
calcification of outer rim of annulus fibrosis, bamboo spine;
ankylosing spondylitis
Term
impaired renal function, dehydration, acidosis, low-dose aspirin, diuretics, levodopa, lead, ethanol, cyclosporine, hypothyroidism, pyrazinamide
Definition
all cause decreased urate excretion
Term
ethanol, myeloproliferative disease, ineffective erythropoiesis (sickle cell, thalassemia), widespred psoriasis, cytotoxic drugs, glycogen storage disease, G6PD def, HGPRTase def, increased PRPP synthetase activity
Definition
increased urate production
Term
most significant stimulus to uric acid overproduction
Definition
alcohol--> can increase de novo synthesis thru effects on ATP metabolism
Term
2/3 of pts with gout are due to....
Definition
impairment of renal clearnace of uric acid
Term
uricosuric
Definition
probenecid
Term
drug of choice in a patient with gout and concurrent nephropathy
Definition
allopurinol (better for kidneys, but still toxic) or febuxostate (nonpurine inhibitor of xanthine oxidase)
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