Term
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Definition
| Activation leading to proliferation |
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Term
|
Definition
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Term
| Where does central tolerance occur |
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Definition
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Term
|
Definition
| immature lympho. when presented w self antigens are instructed to apoptosize if they react |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| Mature T cells preseneted with a self antigen will be innactivated |
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Term
|
Definition
| Innactivation of mature T cells |
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Term
|
Definition
| AutoImmune REgulator- protein in thymus that presents perephrial protein antigens |
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Term
|
Definition
| AI Polyendocrine Syndrome |
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Term
|
Definition
| Costimulators of immune response of T cells |
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Term
|
Definition
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|
Term
| Cytotoxic T Lymphocye antigen 4 (CTLA4) |
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Definition
| shuts off T cell response, but can also recognize B7 and lead to activation |
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Term
|
Definition
| Block the formation of lymphocyte proliferation if they are active against Self. |
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Term
|
Definition
| Transcription factor used by CD25, Il-2 alpha receptor. TGF-B uses Foxp3 to help block stimulation |
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Term
|
Definition
Excessive proapoptotic proteins leads to mitochondrial leak of proteins and caspases
Normal antiapoptotic protein produced but no costimulation leads to death
Death receptor: FAS protein(CD95:memory cells) and FAS ligand (FASL: TCELLS) leads to apoptosis when combined |
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|
Term
| Autoimmine Lymphoproliforative Syndrome |
|
Definition
| Mutation in apoptosis mechanisms |
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|
Term
| B Cells adaptibility to self antigens |
|
Definition
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Term
|
Definition
| New IG chain producted and makes new receptor |
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Term
|
Definition
| defective T and B cell tolerance |
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|
Term
| B Cell + Antigen with no T cell help |
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Definition
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Term
|
Definition
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Term
|
Definition
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Term
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Definition
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Term
|
Definition
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Term
|
Definition
| autoimmune polyendocrine syndrome- defective T cell elimination |
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Term
|
Definition
| ALPS- AI Lymphocyte proliferation syndrome |
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Term
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Definition
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Term
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Definition
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