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Cartilage
Important words and concepts
13
Biology
Graduate
09/18/2014

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Term
cartilege general considerations
Definition
fast forming, light and flexible much intercellular substance, non-vascular nutrients supplied by diffusion through ct matrix
Term
2 main cells state and breifly describe
Definition
Chondroblast: young progenitor come from mesenchumal cells or multpotential ct cells differentiate to produce cartilage matrix; chondrocyte: mature located within lacunae contain golgi complex RER and frequently fat droplet
Term
Intercellular matrix
Definition
fibers-depend on type of cartilage, ground substance: predominately chondroitin sulfates which imparts a bluish stain on H&E, more concentrated around the lacunae
Term
Lacune
Definition
meaning little lake houses chondrocytes embedded with in cartilege relatively devoid of groundsubstance
Term
interterritorial matrix
Definition
area of cartilege with exception of the areas occupied by lacunae, is rich in gound substance and fibers
Term
teritorial matrix
Definition
fluid filled matrix in the lacunae occupied by chondrocytes
Term
perichondrium state and describe the two layers that make it
Definition
is where new cartilege cells are derived. Composed of a fibrous layer: dense regular CT (parrallel collagen fibers) and chondrogenic layer: bleds gradually into cartilage, where chondrogenesis occurs
Term
2 types of growth state and breifly describe each
Definition
Appositional: (add) chondroblasts of the CG layer secrete matrix interstitial: chondrocytes divide producing isogenous groups/units
Term
name the three types of cartilage
Definition
Hyalin, elastic, fibrocartilage
Term
Hyaline describe and where distribution
Definition
composed mainly of collagen type 2 fribrils have similar refractive index as groundsubstance, diributed in fetal skeleton, articular cartilage of bone surfaces at joints, nose larynx treachia bronchi
Term
Elastic Cartilage
Definition
also composed of type 2 collagen fiber component of matrix is abundant forms dense branching network almost obscures groundsubstance very little groundsubstanc, chondrocytes are larger then hylin often have fat bodies framwork of hematopoeitic areas spleen bone marrow lymppoids organs distributed in ear epiglottis and parts of larynx
Term
Fibrocartlage
Definition
never occurs alone but blend with neighboring hyalin cartilage fiborous tissue or bone, bundles of fiber, bundles of collagen fill matrix, chondrocytes may appear in parallel rows or randomly distributed, occur lacunae minimal ground substance , functions: provides stiffnessand great tensile strength at tendon insertions, transitions form between dense FECT and cartilege, shock absorber, distribution: annulus fibrosus which covers the intervertebreal disc gel like mass derived from the notocord, pubic symphasis, and attatchment of some tendens to bones
Term
Stages of calcification
Definition
chondrocytes hypertrophy, produve alk phosphatase with provides calcifiable matrix, calcium phosphate deposted in matrix which prevents diffusion of nurtients kill chondrocyte leaving behind matrix
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