Term
| Signs of Left Heart Failure |
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Definition
| Pulmonary congestion (SOB), left ventricular hypertrophy, edema, tachycardia |
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Term
| Signs of right heart failure |
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Definition
| Venous HTN, pitting edema, hepatomegaly, anorexia |
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Term
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Definition
*anorxia, NVD, confusion, blurred vision (halos), *dysrhythmias
Toxicity made much worse by *hypokalemia or anything that decreases dig clearance
Narrow TI: 0.5-0.8 ng/ml |
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Term
| Digoxin (Lanoxin) effects |
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Definition
Cardiac glycoside PO
Increase heart contractility by inhibiting Na-K ATPase (increasing Ca entry into cell) leading to increased CO
Decreased HR = more time to fill empty heart
Decrease AV nodal conduction |
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Term
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Definition
| Based on lean body weight. 70% renally excreted - good renal function important or adjustment in dosage is necessary |
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Term
| Digoxin (Lanoxin) pharmocokinetics |
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Definition
| Good PO absorption, but tablets < capsules. Don't switch dosage forms!!! |
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Term
| Digoxin (Lanoxin) toxicity treatment |
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Definition
| d/c dig, correct K+, administer Digibind (antibodies to dig that pull it out of circulation - time important b/c dig must not be absorbed already) |
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Term
| Digoxin (Lanoxin) drug interactions |
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Definition
Quinidine: displaces dig from tissues, decreases dig excretion. Decrease dig dose when using quinidine
Antacids: bind dig, decrease absorption
Diuretics: cause hypokalemia, increase dig toxicity |
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Term
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Definition
| Plays major role in maintaining fluid balance in body (also worsens CHF)by acting as vasoconstrictor (increasing pre + afterload) & by stimulating release of aldosterone from adrenal cortex |
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Term
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Definition
Decreased TPR & blood volume
SE: in some patients a cough; increase in serum K+, dizziness. Angioedema is a life-threatening SE |
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Term
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Definition
1st line treatment for CHF.
Captopril, *Enalapril, *Lisinopril, Fosinopril, Quinapril
Ramapril & Trandolapril - approved for HF following MI
Also used for HTN |
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Term
| Dobutamine (Dobutrex) & *Milrinone (Primacor) |
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Definition
Vasodilators & cardiac stimulants
Short term treatment |
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Term
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Definition
Sometimes used
Decrease HR - be careful!! |
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