Term
|
Definition
|
|
Term
|
Definition
| Carry cholesterol & TG to tissues: Forms a platform for clot formation |
|
|
Term
|
Definition
| Carries dietary fat to tissues |
|
|
Term
|
Definition
| Removes cholesterol from tissues to liver |
|
|
Term
Atorvastatin (Lipitor)
Simvastatin (Zocor)
Rosuvastatin (Crestor) |
|
Definition
HMG-CoA reductase inhibitor
Inhibits cholesterol synthesis in liver --> decrease LDL-C in serum. Upregulates LDL receptors --> increase catabolic clearance of serum LDL-C
Significant decrease serum LDL-C
Modest increase HDL-C, decrease TG
May also decrease C-reactive protein
Lipitor produces most rapid decrease in LDL-C |
|
|
Term
|
Definition
| Associated w/ inflammatory process in atherosclerosis |
|
|
Term
Liver Function Test (LFT):
Atorvastatin (Lipitor)
Rosuvastatin (Crestor) |
|
Definition
| Monitor at 12 wks, then every 6 months |
|
|
Term
|
Definition
Monitor at 6 & 12 months
& 3 months if 80mg/day is used |
|
|
Term
|
Definition
All decrease risk of MI &/or mortality (but not for 2 yrs)
All well absorbed PO
Administer in evening (not needed in Lipitor): increase hepatic cholesterol synthesis at night
SE: hepatotoxicity, do not take while pregnant |
|
|
Term
Gemfibrozil (Lopid)
Fenofibrate (Tricor)
Ezetimibe (Zetia) |
|
Definition
Fibric acid derivatives
Increase lipoprotein lipase activity; decrease lipolysis in adipose issue; decrease hepatic uptake of fatty acids
Effectively decrease TG & VLDL-C; increase HDL-C
Concurrent use w/ statins may increase risk of myositis & rhabdomyolysis. Also increases risk of hepatotoxicity *Monitor LFTs |
|
|
Term
Cholestyramine (Questran)
Colesevelam (Welchol)
Ezetimibe (Zetia) |
|
Definition
Bile Acid sequesterants
Bind to bile acids in intestines --> fecal excretion. Body upregulates LDL receptors --> increase catabolism of LDL-C in liver. Blocks cholesterol absorption
*May interfere w/ fat & fat-soluble vit. absorption; interferes w/ absorption of other drugs: bid/tid dosing (take 1h before or 4h after) |
|
|
Term
Nicotinic acid (Niacin, Niaspan)
Is a vitamin |
|
Definition
Inhibits lipolysis in adipose tissue; decreases hepatic production of VLDL-->decrease serum TG & LDL-C
Least $$ of all; *most effective at decreasing TG & increasing HDL-C
*Monitor LFTs as w/ statins
Use caution in diabetics & gout
SE: cutabneous flushing; decreases w/ continued use |
|
|
Term
|
Definition
Less than or equal to 200 mg/dL
Treat w/ diet |
|
|
Term
|
Definition
200-399 mg/dL
Treat w/ diet & possibly then drugs |
|
|
Term
|
Definition
Greater than or equal to 400 mg/dL
Treat w/ diet & drugs |
|
|
Term
|
Definition
Fish oil (Lovaza as prescription pill)
Some evidence for flax seed oil
Complaints: fish odor & taste, & GI disturbances
Take w/ meals |
|
|
