Term
3 Main drugs to treat excessive clot formation
1. Anticoagulants
2. ___________
3. Thrombolytics |
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Definition
1. Anticoagulants
2. Antithrombotics
3. Thrombolytics
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Term
There a 4 drugs mentioned that were classified as anticogulants the include...
1. _______
2. Low Molecular Weight Heparin
3. ________ (Coumadin)
4. Fondaparinux (Arixtra) |
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Definition
1. Heparin
2. Low Molecular Weight Heparin
3. Warfarin (Coumadin)
4. Fondaparinux (Arixtra) |
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Term
Heparin
Action: ________
Therapeutic Effect: Prevents Clot Formation, prevents extension of existing venous thromboembolism (VTE prophylaxis)
Side Effects: _______________ |
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Definition
Action:
1.Potentiates Antithrombin
2.Renders clotting factors inactive; inhibits synthesis and function of clotting factors.
Therapeutic Effect: Prevents clot formation, prevents extension of exsisting venours thromboembolism (VTE prophylaxis)
Side Effects: Bleeding, thrombocytopenia, HIT heparin induced thrombosis. |
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Term
Low Molecular Weight Heparin
(Lovenox, Fragmin)
Action: Inhibit synthesis of clotting factors.
Therapeutic Effect: _________
Side Effects: Bleeding (intra-abdominal) |
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Definition
Action:
Inhibit synthesis of clotting factors.
Therapeutic Effect:
prevention of clot formation and prevention of extension of an exsisting venous thromboembolism.
Side Effects: Bleeding (intra-abdominal) |
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Term
Warfarin (Coumadin)
Action: _______
Therapeutic Effects: _____________
Side Effects: Bleeding |
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Definition
Action:
1. Inhibits Vitamin K.
2. Decreased synthesis of clotting factors II, VII, IX, X
Therapeutic Effects: Long term prevention of blood clots in persons with valve replacements, atrial fibrillation, DVT hx.
Side Effects: Bleeding
Note: requires long term lab analysis of PT/INR |
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Term
Fondaparinux (Arixtra)
Action:
1. Inhibits clotting factor Xa.
2. Prevention of clot formation.
Therapeutic Effect: ____________
Side Effects: Bleeding, intra-abdominal, intra-cerebral. |
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Definition
Action:
1. Inhibits clotting factor Xa.
2. Prevention of clot formation.
Therapeutic Effect:
Prevention of venous (VTE) thromboembolism for patients at risk ex: post op orthopedic surgery; immobile.
Side Effects: Bleeding, intra-abdominal, intra-cerebral.
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Term
There were 2 drugs mentioned that are classified as Antithrombotics ther were.....
1. _______
2. Clopidogrel (Plavix) |
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Definition
1. Aspirin
2. Clopidogrel (Plavix) |
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Term
Aspirin
Action: _____________
Therapeutic Effects: _____________
Side Effects: GI upset, GI bleeding, tinnitus at high doses. |
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Definition
Action:
1. Suppresses of proaggregation substances.
2. Inhibition of platelet aggregation.
Therapeutic Effects:
Prevention of myocardial infarction, prevention of cerebral ischemia/stroke.
Side Effects: GI upset, GI bleeding, tinnitus at high doses.
Notes: Can prevent colon cancer.
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Term
Clopidogrel (Plavix)
[ADP Receptor Inhibitors]
Action : Inhibits ADP (a compund that increases platelet activity)
Therapeutic Effect: _________
Side Effects: Bleeding |
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Definition
Action : Inhibits ADP (a compund that increases platelet activity)
Therapeutic Effect:
Prevention of myocardial infarction and ischemic stroke.
Side Effects: Bleeding
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Term
There was one Thrombolytic that was mentioned and its name was....
1. _________________________ |
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Definition
Streptokinase (Streptase) |
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Term
Streptokinase
Action: Converts plasmogin to plasmin the enzyme which breaks down clots.
Therapeutic Effects: ____________
Side Effects: Intracerebral hemorrhage; bleeding ; peripheral arterial occlusions. |
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Definition
Action:
Converts plasmogin to plasmin the enzyme which breaks down clots.
Therapeutic Effects:
Treatment of ischemic strokes, myocardial infarctions; treatment of peripheral arterial occlusions; treatment of occluded venous access devices.
Side Effects: Intracerebral hemorrhage; bleeding; peripheral arterial occlusions.
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Term
3 Main Agents used to treat hyperlipidemia
1. HMG-CoA Reductase Inhibitors (Statins)
2. ______ ____ ______
3. Cholesterol Absorption Inhibitor |
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Definition
1. HMG-CoA Reductase Inhibitors (Statins)
2. Fibric Acid Agents
3. Cholesterol Absorption Inhibitor
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Term
Statins
Action: ________
Therapeutic Effects: Decrease levels of LDL and triglycerids with moderate increase in HDL.
Side Effects: ___________ |
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Definition
Action:
1. Inhibits enzyme.
2. Decrease Cholesterol Production.
Therapeutic Effects: Decrease levels of LDL and triglycerids with moderate increase in HDL.
Side Effects:
Nausea, cramping, myopathies, rhabdomylysis, liver dysfunction.
Rhabdomyolysis= breaking down of all muscle fibers.
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Term
Fibric Acid Agents
Action: Mechanism is unknown.
Therapeutic Effect: _________
Side Effects: Abdominal pain, fatigue, nausea and vomiting, liver dysfunction. |
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Definition
Action:
Mechanism is unknown.
Therapeutic Effect:
Decreases trigylceride levels, increased HDL.
Side Effects:
Abdominal pain, fatigue, nausea and vomiting, liver dysfunction.
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Term
Cholesterol Absorption Inhibitors
Action : _________
Therapeutic Effect: Reduces LDL & triglycerides; increased HDL.
Side Effects: GI distress, abdominal pain. |
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Definition
Action :
Inhibits cholesterol absorption production in the GI tract.
Therapeutic Effect:
Reduces LDL & triglycerides; increased HDL.
Side Effects: GI distress, abdominal pain.
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