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Cardiovascular Lecture 3
Dr. Lokuta notes UW Madison
26
Physiology
Undergraduate 4
04/18/2012

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Term
CONDUCTION VELOCITY FOR EACH RESPECTIVE CELL IS DETERMINED BY
Definition
THE SLOPE OF PHASE 0 (UPSTROKE)
WHAT HAPPENS AFTER THRESHOLD IS REACHED
Term
WHAT DETERMINES AUTOMATICITY IS...
Definition
THE SLOPE OF PASE 4, THE DIASTOLIC DEPOLARIZATION
WHAT HAPPENS BEFORE THRESHOLD, HOW FAST YOU GET TO THRESHOLD.

LAB DEMO HR/POKING
SA NODE TO GAP JUNCTION
Term
COMPARISON OF CONDUCTION VELOCITIES
Definition
SA NODE .1M/SEC
AV NODE .01 M/SEC
CONDUCTION SYS (BUNDLE OF HIS ETC) 3-4 M/S *******
VENTRICULAR MUSCLE CELLS 1M/S
Term
how diastolic depolarization affects pacemaker
Definition
automaticity or speed/rate to reach threshold
slower depol. diminishes firing frequency
Term
two other ways (besides slower (less steep slope) diastolic depolar)to diminish firing frequency of pacemaker cell
Definition
1) increase threshold potential
2) increase magnitude of maximum diastolic potential.
Term
Normal sinus rhythm
tachycardia EKG
Sinus bradycardia EKG
Definition
Term
SA, First degree AV block
Definition
PR interval .28 seconds normal is less than .2 seconds Sometimes lacks QRS
Term
Second degree AV block
Definition
2:1 P wave depolarization and repolarization sometimes lacks ventricular complex waves entirely and only has P waves
Term
Third degree AV block
Definition
after ventricular complex waves T wave is inverted almost
followed by P wave
some ventricular complex waves missing entirely.
Term
Important Diff between AP's/Twitch in Cardiac vs. skeletal muscle
Definition
Skeletal muscle can summate and recruit to increase force
CARDIAC MUSCLE CANNOT SUMMATE OR RECRUIT TO INCREASE FORCE

CARDIAC MUSCLE HAS A PROLONGED REFRACTORY PERIOD TO ENFORCE RELAXATION.

PROLONGED REFRACTORY PERIOD PREVENTS TETANUS AND ALLOWS TIME FOR VENTRICLES TO FILL WITH BLOOD PRIOR TO PUMPING.
Term
DIASTOLE
Definition
RELAXATION
2/3 OF TIME
Term
SYSTOLE
Definition
CONTRACTION
1/3 OF TIME SPENT IN HEART.
ISOVOLUMETRIC CONTRACTION WHICH DEVELOPS PRESSURE LIKE CLOSE SYRINGE
Term
4 PHASES (REF TO L VENTRICLE BY DEFAULT)
Definition
1 VENTRICULAR FILLING (DIASTOLE)
2 ISOVOLUMETRIC CONTRACTION (SYSTOLE)
3 EJECTION - SYSTOLE
4 ISOVOLUMETRIC RELAXATION- DIASTOLE
Term
DIASTOLIC VENTRICULAR FILLING
Definition
1 ATRIA RELAXED THEREFORE PASSIVE FILLING
2 ATRIA CONTRACT---ATRIAL KICK ADDS 10-20% MORE BLOOD AND IS ACTIVE.
Term
END DIASTOLIC VOLUME (EDV)
Definition
-135 MLS AT REST
Term
SV=
Definition
EDV-ESV
Term
GRAPH OF EDV RELATED TO LUB-DUP
Definition
65 ESV RISES DURING FILLING ATRIAL KICK GETS TO 135 ML
ISOVOL CONTRACTION BEGINS --LUB--
EJECT SV 70 ML AND SLOPE DOWN TO VENTRICULAR RELAXATION --DUP--
Term
LUB DUP
Definition
LUB- R WAVE, ISOVOLUMETRIC VENTRICULAR CONTRACTION (SYSTOLE)
AV VALVE CLOSING

DUP- T WAVE, VENTRICULAR RELAXATION
Term
PRESSURE IN CHAMBERS DURING LUB OF SYSTOLE
Definition
ALL VALVES CLOSED
P IN VENTRICLES < PRESSURE IN AORTA AND PA
P IN VENTRICLES > THAN IN ATRIUM ---> PAPPILARY MUSCLES AND CHORDAE TENDINAE KEEP AV VALVES FROM INVERTING!
Term
EJECTION SYSTOLE PRESSURE STUFF
Definition
AORTIC AND PULMONARY VALVES OPEN
AV CLOSED

P IN VENTRICLES > P IN AORTA AND PA

SV AT REST 70 WHAT IS EJECTED FROM EACH VENTRICLE
SV IS SAME FROM L AND R VENTRICLES
Term
END SYSTOLIC VOLUME
Definition
ESV
ESV=EDV-SV
=135-70
=65
65 MLS
Term
ISOVOLUMETRIC RELAXATION DIASTOLE
SOUND AND PRESSURE STUFF
Definition
DUP - SEMILUNAR VALVES CLOSING
SECOND HEART SOUND AT START OF PHASE
CONSTANT VOLUME AT ESV
P IN VENTRICLES < P IN AORTA AND pa
P IN VENTRICLES > PRESSURE IN ATRIA
Term
LAMINAR FLOW
TURBULANT FLOW
STENOSIS
INSUFFICIENCY
Definition
-SMOOTH AND QUIET/HEALTHY MAX VELOCITY PARALLEL WITH TUBE QUIETTTTTT NO BACK FLOW IN CLOSED

- FLUID MOVE IRREGULARLY IN AIAL RADIAL AND CIRCUMFERENTIAL DIRECTIONS. VORTICES DEVELOP

-POOR OPENING OF VALVE = STENOISIS MURMOR=
WHISTLE SOUND DUE TO NARROWED VALVE

-INSUFFICEIENT VALVE CLOSURE IS LEAKY AND BACKFLOW LEADS TO A MURMUR THAT IS A GURGLE
Term
INAPPROPRIATE VOLUME LEADS TO ...
Definition
ABNORMALLY HIGH PRESSURE PRE-VALVE SIDE
Term
Arterial BP waveform AND CORRESPONDING FORMULAS
1-8
Definition
-1 ventricular ejection = rise in BP
-2 ventricular filling (diastole) decreases aortic BP
-3 ejection and diastolic compliance (AORTA IS ALREADY PRESSURIZED SO WALLS OF AORTA HAVE TO EXPAND= COMPLIANCE)
-4 elastic recoil pushes blood out to body from aorta, closes semilunar valves during ventricle relaxation decreases pressure
-5 dichrotic notch is brief repressurization due to aortic valve closing
-6 systolic pressure is peak
-7 diastolic pressure is valley
-8 pulse pressure is PP= SP-DP
-9 MAP= P DIAS+ (PP/3)
Term
BLOOD PRESSURE CUFF SOUNDS
Definition
FIRST SOUND IS WHEN PRESSURE IN CUFF NO LONGER EXCEDES SP. SO BLOOD CAN NOW RUSH THROUGH ARTERY AND FIRST SOUND IS HEARD

WHEN CUFF PRESSURE IS BELOW THE DIASTOLIC PRESSURE, NO SOUNDS ARE AUDIBLE BECAUSE IT IS CONTINUOUS FLOW
LACK OF SOUND

INBETWEEN SP AND DP KOROTKOFF SOUNDS HEARD FROM SPURTS OF BLOOD IN ARTERY WITH EACH HEART BEAT
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