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Cardiovascular IV
Dr. Lokuta Lecture notes
5
Physiology
Undergraduate 4
04/21/2012

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Term
three implications of frank starling relationship
Definition
1- CONTROL OF END SYSTOLIC VOLUME (PREVENTS ESV FROM INCREASING THEREFORE PREVENT CLOTTING)

2- MATCHING OF LV AND RV OUTPUT

3- PREVENTION OF RISE IN VENOUS PRESSURE
(PREVENT BLOOD FROM BACKING UP IN VEINS/CAPS... BC VR= PRELOAD
AND VR DETERMINES EDV
Term
HOW TO INCREASE FORCE OF CONTRACTION
Definition
INCREASE EDV AND FILL MORE!
Term
3 WAYS TO ALTER MYOFILAMENTS
BIGGER TRIGGER
BIGGER RESPONSE
Definition
CHANGE AFFINITY OF TROPONIN FOR CA++

INCREASE AMOUNT OF CA++ RELEASED MORE TROPONIN SATURATION

INCREASE Pi RELEASE THUS INCREASING CYCLING RATE AND INCREASING SR PUMP ACTIVITY THUS AIDING IN FASTER RELAXATION
Term
HOW DOES PARASYM INHIBIT SYMPATHETIC CASCADE
Definition
INHIBIT PRODUCTION OF cAMP BY ADENYLATE CYCLASE.

(M-ACH--> Gi----> AC )
Term
AFTERLOAD AFFECTS STROKE VOLUME
Definition
AFTERLOAD IS DUE TO MABP

IF YOU ASSUME EQUAL CONTRACTILITY AND EDV... HIGH MABP DECREASES STROKE VOLUME.

SO... HIGH MABP REDUCES CARDIAC OUTPUT ULTIMATELY.
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