Term
| vascular injury and vasculitis |
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Definition
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Term
| conduct blood to tissues; transport oxygen, nutrients, wastes and drugs |
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Definition
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Term
| maintenance of permeability barrier; source of anticoagulant/antithrombotic molecules |
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Definition
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Term
| prostacyclin, thrombomodulin, plasminogen activator, heparin-like molecules |
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Definition
| anti-coagulant/antithrombotic molecules |
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Term
| von Willebrand factor, tissue factor, PA inhibitor |
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Definition
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|
Term
| vasoconstrictors, vasodilators |
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Definition
| modulation of blood flow and vascular reactivity |
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Term
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Definition
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|
Term
| nitric oxide, prostacyclin |
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Definition
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|
Term
| other functions of endothelial cells |
|
Definition
| modulation of blood flow, regulation of inflammation/immunity, regulation of cell growth; oxidation of LDL |
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Term
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Definition
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Term
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Definition
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Term
| release of growth factors and cytokines; migration and proliferation |
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Definition
| vascular smooth muscle functions |
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Term
| mechanisms of drug-induced vascular injury |
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Definition
| biomechanical injury; toxicity following direct pharmacological and/or chemical perturbation; injury via immune-mediated mechanisms |
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Term
| affecting mainly large- and medium- sized arteries |
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Definition
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Term
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Definition
| Methylxanthinese (caffeine, theophylline); potassium channel activators (minoxidil, diazoxide) |
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|
Term
| potassium channel activators |
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Definition
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|
Term
| affecting mainly small arteries andarterioles |
|
Definition
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|
Term
|
Definition
| vasopressin, angiotensin II, epinephrine, phenylepinephrine, methoxamine |
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|
Term
| drug induced vascular injury |
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Definition
| vasodilators, vasoconstrictors, exacerbation of pre-existing pathology (atherosclerosis) |
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|
Term
| exacerbation of pre-existing pathology (atherosclerosis) |
|
Definition
| cholesterol and oxygenated derivatives; organophosphates; cadmium, arsenics, mercury |
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|
Term
| a heterogenous group of disorders characterized by inflammatory destruction of both arteries and veins |
|
Definition
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|
Term
|
Definition
| propylthiouracil, ciprofloxacin |
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