Term
|
Definition
| membrane-bound organelles in endothelial cells that contain vWF. |
|
|
Term
| How do endothelial cells control the transfer of small and large molecules across the vascular wall? |
|
Definition
Hemodynamic factors (HTN, etc...) and vasoactive agents (histamines, etc...)
These influence the size of the gaps b/w the ECs |
|
|
Term
| What role do Endothelial Cells play? |
|
Definition
non-thrombotic blood-tissue interface by modulating:
1. vascular resistance
2. hormone metabolism
3. regulate immune/inflammatory rxns
4. regulate other cell's growth
5.influence vasoreactivity of smooth muscle |
|
|
Term
How do endothelial cells influence the vasoactivity of underlying smooth muscle?
|
|
Definition
Produce relaxing factors--> NO
or
Constricting factors--> endothelin
Normal EC fxn--> balance these factors and respond to pharmacological stimuli (ACh or NE) |
|
|
Term
| How does Endothelial Cell dysfunction manifest? |
|
Definition
| as a changed phenotype that impairs vasoreactivity or induces a surface that is thrombogenic or abnormally adhesive to inflammatory cells |
|
|
Term
| What pathologic stimuli do Endothelial cells respond to? |
|
Definition
| cytokines, bacterial products, hemodynamic stress, lipid products, glycosylation end products, viruses, complement, hypoxia |
|
|
Term
| How do edothelial cells respond to pathologic stimuli? |
|
Definition
| they express adhesion molecules, produce cytokines, chemokines, growth factors, wasoactive molecules, MHC molecules, and pro/anticoagulative moieties |
|
|
Term
| Smooth Muscle Cells (SMCs) |
|
Definition
predominent cellular componenet of vascular media. Responsible
1. vasoconstriction/dilation in response to pharmacological stimuli
2. synthesize: collagen, elastin, proteoglycans, elaborate growth factors, cytokines |
|
|
Term
| How do SMCs respond to vascular injury? |
|
Definition
| They migrate to intima and proliferate |
|
|
