Term
|
Definition
| Atorvastatin, Rosuvastatin, Simvastatin |
|
|
Term
| Risk factors For Statin-induced Myopathy |
|
Definition
Small Frame
Chronic Disease
Age: >80
Post-Op
Meds:
Fibrates/Niacin
Azoles
Macrolide
Verapamil
Amiodarone
HIV protease inhibitors
Grapefruit Juice
Cyclosporine |
|
|
Term
Cholesterol lowering meds?
What is the meachnism of each? |
|
Definition
Statins: HMG-coA Reductase block
LDL, decrease HDL
Cholestyramine
LDL
Fibrates- PPAR-alpha agonist
HDL, TG
Fish Oil-
HDL, TG
Niacin-
HDL, TG |
|
|
Term
| Ways to avoid Niacin Flushing |
|
Definition
| With snack, No spicy food, decrease fat, aspirin |
|
|
Term
| Adverse effects of statins |
|
Definition
|
|
Term
Common Bile Sequestrants
(AKA not in the notes) |
|
Definition
| Colesevelam
Cholestyramine
Colestipol |
|
|
Term
|
Definition
| Block Cholesterol entry in GI |
|
|
Term
| Problems associated with Resin/Bile Sequestrate use |
|
Definition
| Decreased drug and vitamin absorption |
|
|
Term
What cholesterol lowering drug is used first?
What determines which other drugs are added? |
|
Definition
Statin first
After:
Refractory LDL: Add Sequestrant
Low HDL: Niacin, Fish oil, or Fibrate |
|
|
