Term
| What is the CV mechanism of action of organic nitrates? What is the molecular mechanism of action of organic nitrates? |
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Definition
CV: Primarily Venodialation, but also coronary dilation, and arteriole dialation
Molecular: Increase cGMP |
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Term
| Long lasting organic nitrate and problem with its use |
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Definition
| Isosorbide Dinitrate, Tolerance quickly assumes |
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Term
| The channel targeted by Ca-channel Inhibitors |
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Definition
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Term
| What is the difference between the two types Ca-channel inhibitors |
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Definition
Non-Dihydropyradines are negative chronotropes and inotropes
DHP's have reflex Tachycardia |
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Term
| What are the uses of Ca-Channel blockers |
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Definition
Both Types: HPTN, Stable Angina
Non-DHP: Unstable Angina, SVT |
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Term
Why are Beta-Blockers use with DHP's?
Why are Beta-Blockers not used with Non-DHP's? |
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Definition
Prevent reflex Tach with DHP use
Both suppress the heart-> Death |
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Term
| How is Unstable Angina Treated |
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Definition
Rest
B-Block
Antiplatelet and Anticoagulation |
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Term
| How is Variant Angina treated |
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Definition
| Nitrates and Ca-Channel blockers |
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Term
What is the mechanism of Ranolazine
Who is it contraindicated in? |
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Definition
Inhibit late Na current from MI to increase Ca efflux from myocytes
Contraindication: Prolonged QT syndrome |
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