Term
What are the direct acting thrombin inhibitors?
When are they used? |
|
Definition
Hirudin, Bivalrudin
Use: Unstable Angina |
|
|
Term
What is the mechanism of Fondaparinux?
When is Fondaparinux used?
What is the struture? |
|
Definition
Structure:Synthetic Polysacchiride
Use
Deep Vein Thrombosis
Pulmonary Embolism
Mech: Inhibits Xa
|
|
|
Term
| Side Effects of Warfarin/Comadin |
|
Definition
| Teratogenic, Drug Interactions |
|
|
Term
Indication of Warfarin Use
How do you treat an overdose?
What are the side effects of warfarin/coumadin? |
|
Definition
Use
Atrial Fibrillation,
Prosthetic Valve
OD: Vitamin K and factor IX
Adverse:
Teratogenic
Drug Interactions |
|
|
Term
What are the indications for Aspirin
What are the adverse effects? |
|
Definition
Use
High dose: MI
Low Dose:
High risk Prophylactic Stable/Unstable Angina
Coronary Bypass
Adverse
Peptic Ulcers
Some people are resistant |
|
|
Term
What are the common GPIIb/IIIa inhibitors?
What is the mechanism of each GPIIb/IIIa inhibitor? |
|
Definition
Abciximab- Mouse/ Human chimeric Ab
Eptifibatide- Heptapeptide
Tirofiban- Peptidomimetic different site
|
|
|
Term
Mechanism of each Fibrinolytic?
What are the indications for fibrinolytic therapy? |
|
Definition
tPa- Cleaves Plasminogen in Clot
Streptokinase- Activates Plasminogen
Anistreplase- Acetylated Strepto/Plasminogen complex
Uses
Multiple PEs
Central DVT
Acute MI(within golden Window)
Stroke |
|
|
Term
| Mechanism of Low Molecular Weight Heparin |
|
Definition
Inactivates Factor X
Less activity on activation of ATIII |
|
|
Term
| Administration of LMW Heparin |
|
Definition
|
|
Term
| Toxicity of Heparin or LMW Heparin Which is less Toxic? |
|
Definition
Adverse:
HIT: Heparin Induced Thrombocytopenia
Bleeding
Long-term: Osteoporosis
LMW Heparin is less toxic |
|
|
Term
| Indication of LMW Heparin |
|
Definition
| Prevent DVT after surgery |
|
|
Term
| Advantages of Low Molecular Weight Heparin over Heparin |
|
Definition
No Monitoring
No IV Infection
More Convenient
Longer Half-Life |
|
|
Term
| Reversal of Heparin Treatment |
|
Definition
|
|
Term
|
Definition
| Mixture of Sulfated Mucopolysacchirides |
|
|
Term
ADP Platelet Blockers
What is their mechanism?
When are they used? |
|
Definition
Ticlopidine, Clopidogrel
Mechanism: Block ADP biding to PY2 on platelets
Use:
Aspirin Resistance
With aspirin to prevent reocclusion |
|
|
Term
| What circumstances indicate which Thromolytic to use |
|
Definition
tPA: MI golden window
Streoptokinase: All other circumstances bc of cost |
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