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Cardio Pharm Anticholinergics
Cardio Pharm Anticholinergics
14
English
Pre-School
05/12/2009

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Cards

Term
Neuromuscular blocking drugs
Definition
Succinylcholine, Pancuronium (curare)
Term
Succinylcholine: structure and pharmacokinetics
Definition
2 Ach molecules end-to-end that cannot be hydrolyzed; quaternary amine (poor oral bioavailability, no CNS entry)
Term
Succinylcholine: target
Definition
Nicotinic cholinergic receptor
Term
Succinylcholine: mechanism
Definition
Persistant agonist because it cannot be hydrolyzed by AChE. Depolarizing blockade. Short acting
Term
Pancuronium: structure and pharmacokinetics
Definition
2 ACh molecules on steroid nucleus; quaternary amine (poor bioavailability, no CNS entry
Term
Pancuronium: mechanism
Definition
Nicotinic receptor competitive antagonist. Non-depolarizing receptor blockade
Term
Pancuronium: adverse effects
Definition
respiratory paralysis, hypotension (weak ganglion block and histamine release)
Term
Succinylcholine: adverse effects
Definition
respiratory paralysis, bradycardia (weak ganglionic stimulation), prolonged apnea (pseudocholinesterase-degrades succinylcholine-deficiency), malignant hyperthermia (ryanodine receptor defect), hyperkalemia (burn pts, may cause arrhythmias)
Term
Neuromuscular blocking drug: uses
Definition
skeletal muscle relaxation during surgery
Term
Atropine: structure
Definition
tertiary amine (better bioavailability and entry into CNS, eye than ipratropium)
Term
Atropine: mechanism
Definition
competitive antagonist of muscarinic cholinergic receptor
Term
Muscarinic antagonists: classes
Definition
atropine, benzotropine, scopolamine, ipratropium, tiotropium
Term
Muscarinic Antagonist: uses
Definition
Parkinson's, motion sickness, asthma/COPD, post-MI bradycardia, traveller's diarrhea, bladder incontinence, to cause mydriasis and cycloplegia
Term
Muscarinic antagonist: adverse effects
Definition
hyperthermia, intraocular pressure, urinary retention, hallucinations, cycloplegia, dry mouth, flushed skin
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