Term
| Clotting Problems not detected conventionally |
|
Definition
Von Willebrand disease
Factor XIII deficiency
Alpha-2 antiplasm deficiency
Mild Deficiencies |
|
|
Term
| How is a aPTT administered |
|
Definition
| Ca, partial thromboplastin, activators to the plasma |
|
|
Term
| Vitamin K dependent factors |
|
Definition
|
|
Term
| Contents of Platelet Granules |
|
Definition
Alpha: 1,4,5,8, PGDF, TGF-B
Dense: Ca, ADP, ATP, Serotonin, Bradykinin, Epinephrine |
|
|
Term
| Situations of Abnormal clotting testing without factor deficiencies |
|
Definition
| Vit K Deficiency, Warfarin, Liver Cirrhosis, DIC |
|
|
Term
| Physical cues of platelet or vascular disorders |
|
Definition
| Mucosal Bleeding, Petechiae, Certain Vascular Lesions |
|
|
Term
| Congenital Vascular Disorders |
|
Definition
Hereditary Hemorrhagic Telengectasia(Oshler-Weber-Rondu)
Ehler-Danlos |
|
|
Term
| Causes of decreased platelet production |
|
Definition
DRUGS/Radiation, Aplastic, Amegacytosis, marrow Replacement
TAR, B12/Folate Deficiency |
|
|
Term
| Causes of Platelet destruction |
|
Definition
TTP, ITP
DIC, Sepsis, HIV, Marrow Biopsy |
|
|
Term
| Where is Von Willebrand factor found |
|
Definition
| Plasma, Alpha Granules, Weibel-Palade |
|
|
Term
| Diseases of Platelet Dysfunction |
|
Definition
Glanzmans, Bernard-Soulier
Storage Pool, Grey Platelet, Prostaglandin |
|
|
Term
| Pentad of Thrombotic Thrombocytopenia Purpura |
|
Definition
| Thrombocytopenia, Microangiopahic Hemolytic Anemia, CNS, Fever, Renal Insufficiency |
|
|
Term
|
Definition
| Blockage of the metalloprotease for VWF |
|
|
Term
| When is Hemophilia A or B considered severe |
|
Definition
|
|
Term
| What is the treatment for hemophilia A or B |
|
Definition
| DDAVP which increases factor VIII |
|
|
Term
| What is the cause of Hemophilia C |
|
Definition
|
|
Term
| What are causes of Vitamin K deficiency |
|
Definition
| Malnutrition, Warfarin, Antibiotics/Newborn, Malabsorption |
|
|
Term
| TTP variant seen in children |
|
Definition
| Hemolytic Uremic Syndrome |
|
|
Term
| % of Hemophilia cases that are denovo mutations |
|
Definition
|
|
Term
|
Definition
| <45, odd location, Recurrent, Family History |
|
|
Term
| Signs of Homogeneous protein C deficiency |
|
Definition
Cerebral Thrombus
Purpura Fulminans
Skin Necrosis |
|
|
Term
| Causes of acquired protein C deficiency |
|
Definition
ARDS, Hormones
Liver, DIC, Surgery, Warfarin, Asparginase |
|
|
Term
| Epidemiology of Factor V Leiden |
|
Definition
| Scandinavian, Caucasian, 2-6% |
|
|
Term
|
Definition
|
|
Term
| What Hypercoaguability is associated with Spanish poplulations |
|
Definition
|
|
Term
| What is the function of factor C |
|
Definition
|
|
Term
| Diagnosis of Antiphospholipid Syndrome |
|
Definition
1 major+Positive Lupus Anticoag, Ig against Cardiolipin, Positive Snake Venom
Major: Thrombocytopenia, Thrombosis, Miscarriages
Minor: Derm Findings, Gangrene, Ulcers |
|
|
Term
| Treatment of Hyperhomocysteinemia |
|
Definition
|
|
Term
| Signs of Heparin induced Thrombocytopenia |
|
Definition
Heparin Resistance
Platelet decrease after heparin use |
|
|
Term
| When would a heparin Induced Thrombocytopenia present |
|
Definition
| 4-10 days after heparin use |
|
|
Term
| Where is Protein S synthesiszed |
|
Definition
|
|
Term
| Why does factor V leiden make a patient hypercoaguable |
|
Definition
| Resists Protein C degradation |
|
|
Term
| When do signs of prothrombin mutation first appear |
|
Definition
|
|
Term
| What percentage of Lupus patients have Antiphospholipid Syndrome |
|
Definition
|
|
