Term
| Procainamide, Disopyramide, and Quinidine are what class of drug? What is their mechanism of action? |
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Definition
| Class IA; inhibit Na fast channels in activated state(moderate effect) --> decreased phase 4 slope and prolonged QT |
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Term
| Lidocaine is what type of drug? MOA? |
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Definition
| Class IB antiarrhythmic; blocks Na fast channels in inactivated state; mild phase 4 effect - SHORTENS repolarization (decreases duration of AP) |
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Term
| flecainide, propafenone are what drug class? MOA? |
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Definition
| Class IC - marked block on Na channels and big effect on phase 4 - NO effect on repolarization |
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Term
| Metoprolol, Propanolol are what class of antiarrythmic? MOA? |
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Definition
| Class II, slows conduction in pacemaker cells to block reentry arrythmias |
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Term
| Amioarone, dronederone, bretylium, Ibutilide, Dofetilide, and Sotolol are what class of drug? MOA? |
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Definition
| Class III antiarrhthmic; primarily K+ blockade --> prolonged repolarization = increased QT |
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Term
| verapamil and diltiazem are what class of antiarrhythmic? MOA? |
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Definition
| Class IV; CCB - L-type in heart --> works on SA, AV pacemaker cells to prolong repolarization |
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Term
| Adenosine and Digoxin are what type of drugs? MOA? |
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Definition
| Antiarrhythmics; act on pacemaker cells to decrease condution in AV node and rate of pacemaker cell discharge |
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