Term
Inotropic
(Cardiac Drug Effect) |
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Definition
increases force of myocardial contraction |
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Term
Chronotropic
(Cardiac Drug Effect) |
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Definition
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Term
Dromotropic
(Cardiac Drug Effect) |
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Definition
Increase conduction velocity |
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Term
Digoxin
(Cardiac Glucosides)
IM (intramuscular)
Action, ADME, Pharmacological effect, Indications |
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Definition
Action: positive inotrope, nega chronotrope and dromotrope, potent in small doses
ADME: oral, IM, or IV administration; formulation greatly affects absorption, t 1/2=36 hrs, narrow therapeutic range: 0.5-0.8 mg/mL
Pharmacological effects: increases cardiac contractility, decreases electrical conduction rate, indirectly decreases HR, increases Na & H2O excretion
Indications: CHF, atrial fibrillation or other supraventricular dysrhythmia when ventricular rate too rapid
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Term
Digoxin
(Cardiac Glucosides)
Drug-drug interactions & Nursing Considerations |
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Definition
Drug-drug interactions: drugs that reduce absorption or decrease function, drug increase absorption or increase fxn (quinidine, verapamil), antacids, laxatives, cholesterol-lowering agents, ACE/ARB, depress cardiac function or raise BP, beta blockers (OTC decongestants)
Nursing Considerations:Cardiac function, watch HR, dysrhythmias, monitor for Electrolyte imbalances, Check if other drugs change lytes, Renal insufficiency patients, decreases excretion of dig easily get toxic, Female patients death rate is higher |
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Term
Digoxin
(Cardiac Glucosides)
Monitor & SE
n/v-nausea & vommiting |
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Definition
Monitor
-periodic drug levels, electrolyte level (K), change generic formula may need dose adjustment, look HR be4 dosing (apical pulse for min no go if <60)
SE
-Electrolyte imbalances: hypokalemia & hypomagnesemia lead toxcitity (kalemia more common), hyperkalemia and hypercalcemia may produce dysrhythmias
-Toxicity: early-n/v, vision changes & late-dysrhythmias due to progressive heart block (May be fast as if need more medication) |
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Term
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Definition
Binds w/ Immune Fab & excreted by kidney. As more tissue molecules are released into the bloodstream (diffusion), more binding takes place
Hasten elimination by binding with other substances (charcoal, cholestyramine) |
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