Shared Flashcard Set

Details

Carcinogens
Carcinogens and their associated diseases
8
Pathology
Professional
09/22/2011

Additional Pathology Flashcards

 


 

Cards

Term

Polycyclic aromatic hydrocarbons (PAH) 

- mechanism

- disease

Definition

Mechanism:

- from BBQ, tobacco carcinogen is activated by cyt p450

 

Disease: lung and bladder cancer

Term

Aromatic amines and azo dyes

-mechanism

-disease

Definition

Activated by cyt p450; mostly toxic in liver

 

B-napthylamine leads to bladder cancer esp in patients working in rubber and aniline dye industries

Term

Aflatoxin

-mechanism

-disease

Definition

Produced by Aspergillus flavus (fungi)

 

Liver cancer in conjunction with HBV

Term

Alkylating agents

-mechanism

-disease

Definition

Chemo drugs = direct alkylating agents and cause cross-linking of guanosine bases in DNA

 

Therapy related leukemias

Term

Nitrosamines and amides

-mechanism

-disease

Definition

Formed in GI tract from processed foods containing nitrate perservatives that are converted by bacteria to nitrite

 

Contributes to gastric cancer

Term

Asbestos

-disease

Definition
Mesothelioma
Term

Vinyl chloride

-disease

Definition
angiosarcoma of liver
Term

Arsenic

-disease

Definition
skin cancer
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