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Candida: Fungal/Oral Mycology
Microbiology
29
Biology
Professional
01/23/2008

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Cards

Term

 

 

What type of infection is

 

Candida 

 

 

Definition

 

 

 

 

Fungal 

Term

 

 

What does Candida infect 

Definition

 

 

Mucosa 

Term

 

 

What do Aspergillus and Mucor

 

infections typically result from?

 

 

Definition

 

 

 

 

Breakthrough of sinus or nasal infections 

Term

 

 

Candida causes what

 

percent of fungal infections? 

 

Definition

 

 

45 - 50%

Term

 

How is Candida typically acquired? 

Definition

 

50% of humans acqurie it from their mother 

Term

 

Candidia infections associated

 

with low CD4 & T lymphocyte counts

 

cause what type of

 

fungal infection? 

Definition

 

Mucocutaneous 

Term

 

Candida infections that result from

 

low neutorphil counts

 

cause what type of fungal infection? 

Definition

 

Systemic 

Term

 

True or False

 

Yeast infections can be life

 

threatening? 

Definition

 

 

True 

Term

 

Candida albicans (yease infections)

 

prefer

 

low or high pH? 

Definition

 

 

Low pH 

Term

 

Name the three

 

morphologies of

 

C. albicans 

Definition
  • Blastocondidia

  • Pseudohyphae

  • Germ tubes and hyphae
Term

 

Which morphologies are present

 

during fungal infections? 

Definition

 

All three morphologies are present

 

  • Blastoconidia
  • Pseudohyphae
  • Germ tubes and hyphae 
Term

 

Name a few types of

 

oral candidiasis

 

infections 

Definition
  • Denture stomatitis

  • Angular Chelitis

  • Thrush
Term

 

What or the factors in the

 

pathogenesis of

 

oropharyngeal candidiasis?

 

Definition
  • Host

  • Microbial

  • Enviromental
Term

 

What are the functions of

 

saliva? 

Definition
  • Phsico-mechanical - flushing of the oral cavity
  • Tissue coating: lubrication and permeability barrier
  • Modulation of oral flora
  • Antacid and neutralization
  • Regulation of Ca++ and phosphate
  • Digestion
  • Processing of salivary molecules

 

Term

 

Which host factor

 

increases occurance of

 

oropharyngeal candidiasis? 

Definition

 

Hyposalivation

 

frequently caused from underlying disease

 

or therapy 

Term

 

What environmental factors

 

increase occurance of

 

oropharyngeal candidiasis? 

Definition

 

Change in normal bacterial flora

 

and

 

High carbohydrate diet 

Term

 

How does biofilm formation

 

by candida

 

effect successful colonization

 

and infection in the host? 

Definition

 

  • Resistance to immune attack by humoral and cellualar factors
 
  • Resistance to antifungal compounds 
Term

 

Name the three major components

 

of the Candida cell wall

Definition
  • Mannoprotein

  • Glucan

  • Chitin
Term

 

What are the major target

 

for yeast infection treatments?

 

 

Definition
  • Mannoprotein - function: permeability barrier and attachment
  • Glucan -function: structural integrity of cell; highly porous
  • Chitin - function: structural scaffold for growing bud
Term

 

What are the antifungal

 

agents used in treatment of

 

yeast infections? 

Definition
  • Amphotericin B

  • Ravuconazole

  • Echinocandin

 

Term

 

Which antifungal agents are toxic? 

Definition

 

Amphotericin B 

Term

 

Which antifungal agents have a

 

resistance problem?

 

Definition

 

Ravuconazole 

Term

 

What are the CDC

 

recommendations for treatment of

 

Oropharyngeal candidiasis? 

Definition
  • Oral fluconazole

  • Clotrimazole troche

  • Nystatin suspension
Term

 

What is the disadvantage using

 

Nystatin suspension for

 

the treatment of

 

oropharyngeal candidiasis? 

Definition

 

It loses its activity soon

 

after preparation 

Term

 

Name one method to reduce the

 

virulence of  C. albicans

 

in the animal model 

  

Definition

 

Replacement of dietary sugar with

 

xylitol, a sugar substitute 

Term

 

What are the roles in protection

 

against Candida?

 

(four) 

Definition
  • Blocing attachment
  • Direct killing
  • Opsonization and complement fixation
  • Phagocytosis
Term

 

Targeting Candida to phagocyte receptors

 

results in what? 

Definition

 

Increased levels of phagocytosis 

Term

 

Targeting of C. albicans to

 

FcyR leads to what? 

Definition

 

Intracellular organism destruction 

Term

 

Principal behind Photodynamic Therapy

 

(PDT) 

Definition

 

Cells treated with

 

photosensitizing agent

 

undergo cell death when exposed to light 

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