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Cancer
9/1/11 Third Lecture
5
Medical
Graduate
09/01/2011

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Cards

Term
Why do geneticists like to study Drosophila?
Definition
1. Their entire genome has been sequenced

2. 75-80% of human disease genes hafve homologs in Drosophila
Term
What is meant by "Tumors are clonal patches"
Definition
Tumor cells grow in patches and all have the same genotype, but that genotype is different from the normal surrounding cells.
Term
What is the effect of too much Crumbs (Crb)?
Definition
Overgrowth.
Term
What other molecule is necessary for Crb to cause overgrowth and how was it discovered?
Definition
yki

Genetic screening in Drosophila
Term
How do we try to translate the research performed in flies to cancer pathways for humans?
Definition
1. Identify candidates for drug design

2. Facilitate the development of targeted vs. general therapies

3. Genotype tumors to determine pathways and responsiveness to drugs

4. Tailor drugs to genotypes

5. Scalpel vs. Axe
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