Term
| Constant proportion of cell population killed rather than a constant number |
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Definition
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Term
| Treatment with cancer chemotherapy at high doses every 3-4 weeks, too toxic to be used continuously |
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Definition
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Term
| Toxic effect of anticancer drug can be lessened by rescue agents |
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Definition
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Term
Drug used concurrently with toxic anticancer agents to reduce renal precipitation of urate |
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Definition
Allopurinol (Xanthine oxidase inhibitor) - inhibits purine oxidation, allowing purines to be excreted in a form more soluble Increased cell lysis causes hyperuricemia |
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Term
| Pyrimidine analog that causes 'Thymine-less death' given with leucovorin rescue |
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Definition
5-FU (Pyrimidine antagonist, CCS - antimetabolite) |
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Term
| Drug used in CA therapy causes Cushing-like symptoms |
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Definition
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Term
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Definition
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Term
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Definition
| Used for hypoxic tumor stem cells |
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Term
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Definition
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Term
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Definition
Nephrotoxic and Ototoxic (Hydration with IV saline reduces nephrotoxicity) Severe interaction with aminoglycosides |
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Term
| Agent similar to cisplatin, less nephrotoxic but greater myelosuppresion |
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Definition
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Term
| Analog of hypoxanthine, needs HGPRTase for activation |
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Definition
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Term
| Interaction with this drug requires dose reduction of 6-MP |
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Definition
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Term
| Toxicities of Doxorubicin |
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Definition
| myelosuppresion and cardiotoxicity |
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Term
| May protect against doxorubicin toxicity by scavenging free radicals |
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Definition
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Term
| Blows DNA (breaks DNA strands), limiting SE is pulmonary fibrosis |
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Definition
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Term
| Alkylating agent, vesicant that causes tissue damage with extravasation (blisters) |
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Definition
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Term
| Alkylating agent also used in RA, produces acrolein in urine that leads to hemorrhagic cystitis |
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Definition
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Term
| Prevention of cyclophosphamide induced hemorrhagic cystitis |
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Definition
| Hydration and mercaptoethanesulfonate (MESNA) |
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Term
| Microtubule inhibitor that causes peripheral neuropathy, foot drop (ataxia) and 'pins and needles' sensation |
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Definition
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Term
| Interact with microtubules, stabalizes tubulin and cells remain frozen in metaphase |
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Definition
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Term
| Inhibits Topoisomerate II, blocking cell division in late S-G2 phase |
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Definition
| VP-16 (etoposide) or VM-26 (teniposide) |
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Term
| Inhibits topoisomerase I, CCNS |
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Definition
| Topotecan, Irinotecan (Camptothecins) |
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Term
| Converts asparagine to aspartate and ammonia, denies cancer cells of essential AA (asparagine) |
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Definition
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Term
| Used for hairy cell leukemia; it stimulates NK cells |
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Definition
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Term
Antiandrogen used for prostate CA |
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Definition
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Term
| Anti-estrogen used for estrogen receptor + breast CA |
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Definition
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Term
| Aromatase inhibitor used in breast CA |
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Definition
Letrozole, anastrozole No inhibitory effects on adrenals |
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Term
| Newer estrogen receptor antagonist used in advanced breast CA |
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Definition
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Term
| Nonsteroidal inhibitor of corticosteroid synthesis (cholesterol to pregnenolone) and aromatase inhibitor |
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Definition
Aminoglutethamide Causes adrenal insufficiency |
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Term
| GnRH analogs used in advanced prostate CA |
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Definition
| Loeuprolide and goserelin |
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Term
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Definition
| Bleomycin, vinca alkaloids, antimetabolites (5-FU, 6-MP, MTX, etoposide) |
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Term
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Definition
| Alkylating Agents (mechlorethamine, cyclophosphamide) antibiotics (doxorubicin, daunorubicin), cisplatin, nitrosurea |
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Term
| Antiemetics used in association with anti-cancer drugs that are 5-HT3 antagonists |
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Definition
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Term
| Nitrosureas with high lipophilicity, used for brain tumors |
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Definition
| Carmustine (BCNU) and lomustine (CCNU) |
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Term
| Produces disulfirarm-like reaction with ethanol |
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Definition
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Term
| MOPP regimen used in Hodgkin's disease |
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Definition
| Mechlorethamine + oncovorin (vincristine) + procarbazine + prednisone |
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Term
| ABVD regimen used for HD, but appears less likely to cause sterility and secondary malignancies than MOPP |
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Definition
| Adriamycin (doxorubicin) + bleomycin + vinblastine + dacarbazine |
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Term
| Regimen used in non-Hodgkin's lymphoma |
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Definition
| CHOP - cyclophosphamide, doxorubicin, oncovin (vincristine) and prednisone |
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Term
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Definition
CMF - Cyclophosphamide, methotrexate and 5-FU (Tamoxifen if ER+) |
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Term
| Inhibitor of tyrosine kinase domain of Bcr-Abl; used for CML |
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Definition
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Term
| Monoclonal Ab against domain of EGFR |
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Definition
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|
Term
| Folic acid antagonist that binds to DHFR |
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Definition
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|
Term
| Regimen used in treatment of advanced colorectal CA |
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Definition
| FOLFOX (5-FU, Leucovorin, Oxaliplatin) |
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Term
| Inhibits ribonucleotide reductase, which converts ribonucleotides to deoxyribonucleotides for DNA synthesis |
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Definition
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Term
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Definition
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