Term
|
Definition
Class: alkylating agent Mode of action: alkylates DNA bases |
|
|
Term
|
Definition
Class: purine antagonist Mode of action: inhibits purine synthesis |
|
|
Term
|
Definition
Class: pyrimidine antagonist Mode of action: inhibits thymidylate synthesis |
|
|
Term
|
Definition
Class: Anti-tumor anti-biotics Mode of action: intercalates into DNA, inhibits topoisomerase |
|
|
Term
|
Definition
Class: DNA x-linking agents Mode of action: x-links DNA strands, causes single strand breaks |
|
|
Term
|
Definition
Class: mitosis inhibitor Mode of action: inhibits spindle assembly or disassembly |
|
|
Term
|
Definition
| Why is chemo given in a drug cocktail? |
|
|
Term
digestive tract, weight los and vomiting peripheral nerve cells, loss of hands or feet bone marrow, lowered immunity surface cells, mouth sores and hair loss cardiac toxicity, (some more than others) |
|
Definition
SE in 5 areas bc of rapidly dividing cells in these areas: What happens in these 5 areas? |
|
|
Term
peripheral nerve cells and cardiac toxicity |
|
Definition
| What are the 2 areas of the body that suffer SE due to mitochondrial damage? |
|
|
Term
| increased efflux, mediated by MRP and LRP |
|
Definition
| What is the most common drug resistance mechanism? |
|
|
Term
| multiple resistance protein |
|
Definition
|
|
Term
1. lowered uptake 2. increased efflux 3. insufficient activation of drug 4. increased activation of drug 5. drug sequestration 6. mutation in target enzyme 7. increase of target enzyme 8. rapid repair mechanism |
|
Definition
| There are 8 drug resistance mechanisms. What are they? |
|
|
Term
|
Definition
| What is an example of a drug with an increase of target enzyme? |
|
|
Term
1. salvage pathways 2. de novo synthesis |
|
Definition
| What are the 2 ways that nucleotides are provided? |
|
|
Term
attachment of recovered bases to sugar phosphate or phosphate to recovered nucleoside AKA make purine NT by recycling purine bases |
|
Definition
| what is a salvage pathway? |
|
|
Term
|
Definition
| What gives -CH3 to Uracil to make Thymine? |
|
|
Term
|
Definition
| Free bases are ribosylated with _____. |
|
|
Term
| phosphoribosyl pyrophosphate |
|
Definition
|
|
Term
|
Definition
| What converts UDP to dUDP? |
|
|
Term
thymidylate synthase THF to dihydrofolate |
|
Definition
What converts dUMP to TMP? This happens with the conversion of _____ to _____. |
|
|
Term
|
Definition
| What inhibits thymidylate synthase? |
|
|
Term
|
Definition
| What helps convert THF to dihydrofolate? |
|
|
Term
|
Definition
| What inhibits dihyrofolate reductase? |
|
|
Term
|
Definition
| What inhibits the VEGF pathway? |
|
|
Term
|
Definition
| What is a hormone mimetic that works in breast CA, estrogen receptor? |
|
|
Term
|
Definition
| What inhibits the EGF R pathway, kinase inhibitor? |
|
|
Term
| "Herceptin" or trastuzumab |
|
Definition
| What is a monoclonal antibody that works against breast CA, and the HER 2/neu receptor? |
|
|
Term
|
Definition
| What is a monoclonal antibody that works against non-Hodgkins lymphoma, binds CD 20, a B cell surface protein? |
|
|
Term
1. interleukins 2. interferons |
|
Definition
| What are 2 immune system modifiers? |
|
|
Term
1. metastisis inhibitor 2. apoptosis promoter 3. cell cycle inhibitors 4. differentiation stimulators 5. farnesyl transferase inhibitor 6. inhibitor of epigenetics 7. antisense siRNA therapy 8. gene therapy
|
|
Definition
| There are 8 developing approaches to targeted therapies. What are they? |
|
|
