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Cancer terms
Set 1
40
Biology
Undergraduate 3
01/04/2012

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Term
Cancer cell
Definition
are cells that divid and proliferate. These cells are not regulated they constantly divid and sometimes cells do not die. 
Term
Cell proliferation
Definition
cells that are dividing and growing, and differentiating. 
Term
Growth control
Definition
cells that are regulated
Term
Pap test
Definition
in 1928, George Papanicolaou developed a test that is so ismple and straight forward to test for cervial cancer.
Term
Early detection
Definition
results to better the chances of getting rid of all cancer cells through treatment before it metastasizes/ becomes more problematic and life threatening. 
Term
Screening 
Definition
find out if people have disease/ cancer cell by running tests and if so tkae action to treat it
Term
Five year survival 
Definition
based on population statistics. The average maximum years of surivial left once diagnosed with cancer
Term
Carcinogen
Definition
a cancer causing substance or agent
Term
Carcinogensis
Definition
the creation of cancer 
Term
Proto oncogene
Definition
is the normal gene that controls cell division and differentiation but can become an oncogene
Term
Tumor suppressor gene
Definition
suppress cell growth
Term
Growth factors 
Definition
a family of peptide hormones, steroid hormones, that are capable of stimulating cell growth, proliferation and differentiation 
Term
National Cancer Act
Definition
a bill passed by Richard Nixon to fund research fro cancer 
Term
Chemotherapy
Definition
destroys rapid dividing cells. Only method of treatment once caner cells had metastasized. 
Term
NMR
Definition
Nuclear magnetic resonance, other form of treatment without the use of radiation and it similiar to MRI
Term
Oncology
Definition
Onco means tissue mass, therefore they study of tissue mass, tumors. 
Term
Oncologist
Definition
a physician who specializes in the diagnosis and treatment of cancer 
Term
Vogelstein
Definition

- Found the cause of colorectal cancer by a particular gene that was defective and was inherited. This gene is known as FAP/ APC on chromosome 5

- also found DCC gene in 1990, a gene that deleted in the colon carcinoma on chromosome 18, that codes for a protein with a domain similar to neural cell adhesion molecules

- MCC colorectal cancer gene for mutated in colon cancer on chromosome 12

 

 

Term
Rous
Definition
demonstrated that cancer could be transmitted by a virus in 1911 [ Rous sarcoma virus] 
Term
Baltimore
Definition
the discoery of reverse transcriptase an enzyme that synthesizes DNA from RNA template by Baltimore and by Temin in 1970 . 
Term
Weinberg
Definition

The first tumor supressor gene, lines to the childhood cancer retinoblastoma, was cloned at the end 1987 by Dryja, Weinberg and colleagues. When both copies of teh Rb gene which code for a nuclear protein of unknown function are inactivated tumors can form. 

Term
Benign
Definition
  • lacks the ability to metastasize and is not a cancer.
  • It is usually enclosed in a fibrous capsule. 
  • It will not invade normal surrounding tissue.
  • They grow slower than malignant cells and has the potential to become malignant. 
Term
Neoplasm
Definition
  • any abnormal growth of cells or new growth.
  •  Another word for tumor. 
  • An abnormal growth tissue.
  •  A neoplasm may be benign or malignant. The word neo: new + plasma: which is formed or growth= new growth
Term
Tumor
Definition
an abnormal mass of tissue. A classic sign of inflammation can be benign or malignant. 
Term
Carcinoma 
Definition
  • cancer that begins in the skin or tissues that line or cover body organs. An ex. breast, colon, liver, lung, prostate, and stomach. 
  • Are the most common of human tumors 90%. They are malignancies of epithelial cells that cover internal organs. 
Term
Sarcoma
Definition
  • solid tumors of connective tissue and are very rare. 
  • the mesoderm gives rise to connective tissues.  
Term
Leukemia
Definition
  • a cancer of blood and it constitutes 8% of human cancer. 
  • Cancer of the blood is a mesoderm cancer and therefore it can be classified as a type of sarcoma cancer. 
Term
Lymphoma
Definition
a cancer of the lymph system. It involves cells of the immune system, called lymphocytes. 
Term
Clonality
Definition
the fact or condition of being genetically identical, as to a parent, sibling or other biological source. 
Term
Mutation
Definition
occurs when a DNA gene is damaged or changed in such a way as to alter the genetic message carried by that gene
Term
Tumor initiation 
Definition
is a process in which normal cells are changed so that they are able to form tumors
Term
Tumor promotion
Definition
is a process in which existing tumors are stimulated to grow
Term
Tumor progression
Definition

tumor progression involves the transition from normal to malignant cells, through a series of cumulative alterations. During the process, invasive and migratoy properties are required, enabling cells to metastasize. 

Term
Clonal selection
Definition

each lymphocyte bears a single type of receptor with a unique specificity. Receptors occupation is required for a cell activation. The differentiated effector cells derived from an acitvated lymphocyte will bear receptors of identical specificity as the parental cell. Those lymphocytes bearing receptors for self-molecules will be deleted at an early stage. 

Term
Metastasis
Definition
a spread of tumors from primary to secondary sites
Term
Carcinoma in situ
Definition
is an early form of carcinoma defined by the absence of invasion of surrounding tissues. Early stage tumor that hasn't spread yet
Term
Lymphatic system
Definition
the system that produces, stores, and carries the cells that fight infections
Term
Immune system
Definition

a system of biological structures and processes within an organisms that protects against disease by identifying and killing pathogens and tumor cells 

Term
Clincial staging
Definition

a method used to find out the stage of cancer (amound or spread of cancer in the body) using tests that are done before surgery. These include physical exams, imaging tests, labortory tests (such as blood tests) and biopsies. 

Term

TNM 

Definition

a cancer staging system that describes the extent of cancer in a patients body. 

- T: describes the size of the tumor and whether it has invaded nearby tissue

-N: describes regional lymph nodes that are involved

-M: describes distant metastasis (spread of cancer from one body part to another)

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