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CANCER PHARM
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39
Classics
Pre-School
04/19/2013

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Cards

Term
This Drug only works on G2 phase of the cell cycle
Definition
Bleomycin
Term
Which cells are most effected by cancer drugs
Definition
Rapid proliferating cells
Bone marrow
GI tract
Mucosa
Hair Follicles
Gonads
Term
Drugs with Renal Toxicity
Definition
Methotrexate
Cisplatin
Term
Drugs that are Hepatotoxic
Definition
6-MP, Busulfin
Term
Pulmonary Toxic drugs (fibrosis)
Definition
Bleomycin, busulfin
Term
Cardiac Toxic Drugs
Definition
Doxorubicin, daunorubicin
Term
Neurotoxic drugs
Definition
Vincristine (peripheral neuropathy)
Term
Acoustic Nerve damage drugs
Definition
Cisplatin
Term
Major immunosuppressive drugs
Definition
Methotrexate, 6MP, 5FU
Term
Drugs which cause hemorrhagic cystitis
Definition
Cyclophosphamide
Term
Drug which causes pancreatitis
Definition
Asparagylase
Term
Drug is a folic acid analog that inhibits dihydrofolate reductase-> decreases protein synthesis
Definition
Methotrexate
Term
Other uses for methotrexate besides cancer
Definition
Abortion, extopic pregnancy, RA, psoriasis
Term
Rescue drug for Methotrexate
Definition
Leucovarin
Term
Pyrimidine analog bioactivated to 5F-dUMP, which covalently complexes folic acid to decrease thymidylate sythase
Definition
5-Flourouracil
Term
What antifungal medication is turned into 5-flourouracil
Definition
Flucytosin
Term
Rescue for 5-flourouracil tx
Definition
Thymidine
Term
Purine analog activated by HGPRTase
Definition
6-mercaptopurine
Term
Increased toxicity by allopurinal
Definition
6-mercaptopurine
Term
Same mechanism as 6-MP but can be given with allopurinol
Definition
6-thioguanine
Term
Free radicles which noncovalently intercalate DNA.
Also inhibits tropoisomerase
Definition
Doxorubicin and Daunorubicin
Term
Given with Doxorubicin for cardioprotective
Definition
Dexrazoxane
Term
Induces free radical formation, complexes with iron and oxygen
Definition
Bleomycin
Term
Inhibits Topoisomerase II
Definition
Ectoposide/Teniposide
Term
Covalently x link DNA @ N7. Requires bioactivation by the liver
Definition
Cyclophosphamide/ifosfamide
Term
Crosses BBB
Definition
Nitrosoureas
Term
Alkylates DNA with pulmonary fibrosis and hyperpigmentation
Definition
Busulfun
Term
Alkaloids that bind to tubulinin M-phase and block polymerization of microtubules to that mitotic spindle cannot form
Definition
Vinblastine, vincristine
Term
Can cause paralytic Ilieus and alopecia
Definition
Vinblastine, vincristine
Term
Hyperstability polymerized microtubules in M phase so that mitotic spindles cannot brk down
Definition
Pactitaxel
Term
Cross links DNA strands
Definition
Cisplatin/carboplatin
Term
Inhibits ribonucleotide reductase
Definition
Hydroxyurea
Term
SERMS Antagonists in breast and agonists in bone and endometrium
Definition
Tomoxifen
Raloxifen
Term
SERM Used in Breast cancer
Definition
Tomoxifen
Term
SERM used in osteoporosis
Definition
Raloxifene
Term
A monoclonal antibody used against HER-2 (erb-B2) a tyrosine kinase.
Definition
Trastuzamab
Term
Used in CML against the philadelphia chromosome
Definition
Imatinib (bcr-abl)
Term
Monoclonal antibody against CD20 found on most B-cells
Definition
Rituximab
Term
This drug is an alkalating agent used in hodgkin lymphoma and may have the side effect of a leukomogenic
Definition
Procarbazine
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