Term
Alkylating Agents
Indications |
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Definition
Hodgins
Luekemia
Neuroblastoma
Retinoblastoma
Multiple myeloma |
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Term
Alkylating Agents
Aderse rxn's |
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Definition
Myelosuppression plueral effusion
N/V Seizures
Cystitis
Stomatitis
Alopecia
Gonadal suppression
slow toxic with high doses- kidneys, ears
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Term
Alkylating Agents
Nursing Implications |
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Definition
Use immediately after reconstitution
Avoid vapos ineyes
skin contact - flush w/ water
Check placement
Hydrate well - IV + mannitol
watch renals & signs of cystitis
watch hearing & vision
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Term
Antimetabolites
Indications |
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Definition
Acute Lymphocytic & myelocytic leukemia
Brain Tumors
Ovarian, breast, prostate, testicular CA |
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Term
Antimetabolites
adverse rxns |
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Definition
N/V/D
Myelosuppression
proctitis
Stomatitis
Dermatitis
Renal,Hepato - toxic
Anaphylaxis |
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Term
Antimetabolites
Nursing implications |
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Definition
Use antiemetics
use sunscreen
liver/kidney toxic
AVOID ASA, Sulfonamide, folic acid
Leucocorin used w/ methotrexate as antidote
allopurinol w/ 6-MP to inhibit uric acid production by cell destruction = increases drug potency
monitor liver function |
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Term
Antineoplastics
Indications |
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Definition
urea derived = solid tumors & CML
AntiCA enzyme = against all |
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Term
Antineoplastics
Adverse Rxns |
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Definition
Drowsiness
Renal dysfunction
N/V/D
Hepatitis
Myelosuppression |
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Term
Antineoplastics
Nursing Implications |
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Definition
Comfort for stomatitis
GI discomforts
Monitor for complications
Maintaian hydration |
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Term
Plant Alkaloids
Indications |
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Definition
Acute lymphocytic keukemia
Hogkins
Wilm's Tumor (Kidney)
Sarcoma
Breast, testicular CA
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Term
Plant Alkaloids
Adverse Rxns |
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Definition
Myelosuppression
Neurotoxicity - weakness, paresthesia
Jaw pain
Constipation
Stomatitis
Alopecia
HA
Minimal N/V |
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Term
Plant Alkaloids
Nursing Implications |
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Definition
Antiemetics as needed
Monitor for neurotoxicity
Check patency & placement |
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Term
Mitotic Inhibitors
indications |
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Definition
Breast, ovarian CA
Non-small-celllung CA
Kaposi sarcoma |
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Term
Mitotic Inhibitors
Adverse Rxn's |
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Definition
↓ WBCs & RBCs
Alopecia
N/V/D
Joint & muscle pain |
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Term
Mitotic Inhibitors
Nursing implications |
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Definition
signs of infection
Use antiemetics & antidiarrheals |
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Term
Hormonal Agents
Indications |
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Definition
Leukemia
Hodgkins
Breast CA
Lymphoma
Multiple myeloma
Cerebral edema (Due to brain metastasis) |
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Term
Hormonal Agents
Adverse Rxns |
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Definition
Emotional lability Cushing's sym. with OD
Impaired wound healing
Skin fragility
Abnorm fat deposition
Hyperglycemia
Hirsutism (chic-stache)
Moon face
Osteoporosis
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Term
Hormonal Agents
Nursing implications |
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Definition
Taper doses; monitor during withdrawl
Serum K, glucose, Na - weigh daily (report > 5lbs)
Administer w/ antiulcer drugs or food
Care to prevent injury
Teach symtoms Cushings
Monitor BP & pulse |
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Term
Hormonal Agents - Male specific
Indications |
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Definition
Prostate CA
Testicular CA |
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Term
Hormonal - Male specific
Adverse Rxns |
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Definition
HA
Paresthesia
Cardiac arrhythmias
N/V
Hypoglycemia
Neuropathies |
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Term
Hormonal - Male specific
nursing implications |
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Definition
Bone pain
Voiding problems
Safety w/ neuropathies |
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Term
Hormonal - female specific
Indications
Adverse Rxns
Nursing implications |
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Definition
Breast CA
Hot flashes; mild nausea
Use antiemetics |
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Term
Topoisomerase-I Inhibitors
Indications |
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Definition
after failure of initial ovarian Tx
small cell lung
Colorectal CA |
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Term
Topoisomerase-I inhibitors
adverse rxns
Nursing Implications |
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Definition
Myelosuppression
Moderate N/V/D
Use antiemetics
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Term
Monoclonal Antibodies
Indications |
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Definition
targets specific malignant cells w/ less damage to healthy cells in non-Hodgkin lymphoma
Breast CA |
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Term
Monoclonal Antibodies
Adverse Rxns |
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Definition
Fever, chills, infections
N/V/D
Bronchospasms
dysnea
ARDS
Hypotension
Ventricular dysfunction
HF |
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Term
Monoclonal Antibodies
Nursing Implications |
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Definition
Premedicae w/ antiemetics
Monitor for side effects |
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Term
Epogen, Procrit
Indications
Adverse Rxns
Nursing Implications |
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Definition
Anemia due to chronic renal failure
chemotherapy, HIV r/t teatments
Seizures, HTN, Pain at inj. site
Don't shake vial, Monitor HCT levels, Pain at site
Give slowly SubCut |
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Term
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Definition
Impove Immune; increase neutrophils
Medullary bone pain initially tx; pain at site
Monitor WBC/differential absolute neutrophil; Give SubCut slow; Assess bone pain & medicate
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Term
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Definition
Prevent severe thrombocytopenia
Dizzy, HA, insomnia, blurred vision, Pleural effusion, Vasodilation, nevousness, cardiac arrhythmias, bone pain, myalgia, Gi upsets, fluid retention
give slow, access for fluid retention, within 6-24 of chemo & for 10-21 days after, Monitor CBC, H&H, platelets |
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Term
Interferon-alpha-2a & 2b
indications
adverse rxns
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Definition
2a: hairy cell leukemia, karposi sarcoma; 2b:chronic hep B & C, Karposi sarcoma, hairy cell leukemia, AIDS
Seizure, HA, weakness, insomnia, depression, suicide, HTN, angina, vasodilation, edema, palpations, Dysnea, N/V, elevated liver functions, GI disorders, Myalgia, flu-like sym.
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Term
Interferon-alpha-2a & 2b
Nursing Implication |
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Definition
anticipate discomfort-intiate relief,
report depression, use sunscreen (photosensitivity)
Don't shake or swirl, use soon postreconstitution
Monitor CBC & blood chem
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Term
Interfero-beta-1a & 1b
Indications
Adverse Rxns
Nursing Implications |
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Definition
Relapsing Multiple sclerosis, AIDS, Kaposi sarcoma, malinant melanoma, Hep C
Adverse Rxns & Nursing Implications- same as alphas
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Term
Interleukins - Aldesleukin
Indications
Adverse Rxns
Nursing Implications |
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Definition
Metastatic renal cell carcinoma & melanoma skin CA
Resp. failure, pulmonary edema, HF, MI, arrhythmias, stroke, bowel perforation, hepatomegaly, GI disturb, Electrolyte imbalances, coagulation disorders, Pancytopenia
Vigilant monitoring for serios side effect with a stat rsponse |
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