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Cancer Drugs
DIT
22
Pharmacology
Graduate
06/04/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
Methotrexate
Definition
inhibits dihydrofolate reductase. can't make thymidine (a pyrimidine). can cause fibrotic lung disease. rescued by leucovorin.
Term
5-FU
Definition
pyrimidine analogue. inhibits thymidilate synthase. can't be rescued by leucovorin.
Term
6-MP
Definition
purine analogue. inhibits PRPP synthetase. metabolized by xanthine oxidase.
Term
6-Thioguanine
Definition
purine analogue. Inhibits PRPP synthetase. Can be given with allopurinol
Term
cytarabine
Definition
pyrimidine analogue. inhibits DNA polymerase. used for AML.
Term
Cyclophosphamide
Definition
hemorhaggic cystitis. transitional cell bladder cancer.
Term
Nitrosoureas
Definition
end in "-mustine". cross BBB. treat brain tumors. cause neuro probs.
Term
cisplatin
Definition
nephrotoxic and ototoxic
Term
busulfan
Definition
pulmonary fibrosis
Term
doxirubicin
Definition
generates free radicals. intercalates DNA. cardiotoxic.
Term
dactinomycin
Definition
wilms tumor, ewings sarcoma, rhabdomyosarcoma
Term
bleomycin
Definition
fragments DNA, pulmonary fibrosis.
Term
Hydroxyurea
Definition
inhibits ribonucleotide reductase, thereby inhibiting DNA synthesis
Term
etoposide
Definition
inhibits topoisomerase II
Term
prednisone
Definition
triggers apoptosis. used for lymphomas.
Term
tamoxifen
Definition
estrogen antagonist in breast. agonist in bone. partial agonist in endometrium.
Term
trastuzumab
Definition
vs HER2. cardiotoxic.
Term
rituximab
Definition
vs CD20. used for CLL, NHL
Term
Imatinib
Definition
inhibits bcr-abl tyrosine kinase
Term
vincristine
Definition
blocks microtubule polymerization. neurotoxic.
Term
vinblastine
Definition
blocks microtubule polymerization. bone marrow suppression.
Term
paclitaxel
Definition
hyperstabilize microtubules
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