Term
| How does the mechanism of action of methotrexate differ from 5-fluorouracil? |
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Definition
| Both decrease DNA and protein synthesis; folic acid analog that inhibits dihydrofolate reductase (methotrexate) vs. pyrimidine analog that inhibits thymidylate synthase (5-FU) |
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Term
| How does the body metabolize 6-mercaptopurine? |
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Definition
| By xanthine oxidase; purine analog, decreases de novo purine synthesis, activated by HGPRTase |
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Term
| Which anticancer drug is also often used in rheumatoid diseases as well as ectopic pregnancies? |
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Definition
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Term
| For which cancers is dactinomycin particularly useful? |
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Definition
| Wilm’s tumor, Ewing sarcoma, rhabdomyosarcoma, childhood tumors |
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Term
| What drug forms a complex between topoisomerase II and DNA? |
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Definition
|
|
Term
| What drug alkylates DNA, toxicity is pulmonary fibrosis? |
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Definition
|
|
Term
| What drug fragments DNA and also causes pulmonary fibrosis? |
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Definition
|
|
Term
| What drug blocks purine synthesis and is metabolized by xanthine oxidase? |
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Definition
|
|
Term
| What drug cross-links DNA and is nephrotoxic and ototoxic? |
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Definition
|
|
Term
| What drug is a nitrogen mustard that alkylates DNA (an electrophile that binds DNA)? |
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Definition
|
|
Term
| What drug is a folic acid analog that inhibits dihydrofolate reductase? |
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Definition
|
|
Term
| What drug prevents tubulin disassembly? |
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Definition
|
|
Term
| What drug intercalates DNA, produces oxygen free radicals, and is cardiotoxic? |
|
Definition
| Doxorubicin, daunorubicin |
|
|
Term
| What drugs are DNA alkylating agents used in brain cancer? |
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Definition
|
|
Term
| What drugs prevent tubulin assembly? |
|
Definition
|
|
Term
| What drug inhibits thymidylate synthase and thus cause decreased nucleotide synthesis? |
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Definition
|
|
Term
| What drug is SERM and blocks estrogen binding to ER(+) cells? |
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Definition
|
|
Term
| What drug has a mechanism similar to the antivirals acyclovir and foscarnet? |
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Definition
|
|
Term
| What drug has a mechanism similar to fluoroquinolones? |
|
Definition
|
|
Term
| What drug has a mechanism similar to trimethoprim? |
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Definition
|
|
Term
| What drug is a monoclonal antibody against HER-2 (erb-B2) |
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Definition
|
|
Term
| What drug causes free radical-induced DNA strand breakage? |
|
Definition
| Bleomycin, doxorubicin, daunorubicin |
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|
Term
| What drug is the inhibitor of PRPP synthetase? |
|
Definition
|
|
Term
| What drug is reversible with leucovorin? |
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Definition
|
|
Term
| What is the treatment for choriocarcinoma? |
|
Definition
| Vincristine, vinblastine, methotrexate |
|
|
Term
| What is the treatment for AML? |
|
Definition
|
|
Term
| What is the treatment for CML? |
|
Definition
| Busulfan, Imatinib (Gleevac) |
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|
Term
| What prevents breast cancer? |
|
Definition
|
|
Term
| What is the treatment for testicular cancer? |
|
Definition
| EBC (Etoposide, bleomycin, cysplatin) |
|
|
Term
| What is applied topically for AKs and basal cell cancers? |
|
Definition
|
|
Term
| What is the treatment for childhood tumors (Ewing sarcoma, Wilms tumor, rhabdomyosarcoma? |
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Definition
|
|
Term
| What inhibits ribonucleotide reductase? |
|
Definition
|
|
Term
| What causes a side effect of hemorrhagic cystitis? |
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Definition
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|
Term
| What is an inhibitor of the mutated tyrosine kinase produced by the Philadelphia chromosome? |
|
Definition
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|
Term
| What are the potential side effects of prednisone use? |
|
Definition
| Cushingoid features, acne, cataracts, osteoporosis, hyperglycemia/DM, HTN, peptic ulcer, psychosis, insomnia |
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