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C4-16 T-lymphocyte activation & function III.
Took her to the crib
10
Immunology
Professional
11/19/2010

Additional Immunology Flashcards

 


 

Cards

Term





T Cell Activation-What Gets T Cells Going?


 

Definition

1) MHC/peptide + co-stimulatory signal
TCR + CD28
TCR + IL1R
TCR + others

2)Mitogens - Important in clinical evaluation
-PHA
-ConA

3) Antibodies - Used in laboratory
Anti CD3
Anti TCR

4) Chemical Mediators - Used in laboratory
PMA + Calcium ionophores

5) Superantigens




 

Term




T Cell Activation (Proliferation)

Definition

Usually requires 3 separate signals

2 Competence signals
-TCR engagement (signal 1)
-Co-stimulatory signal (signal 2)
1 Progression signal
-IL-2R + IL-2
-Others

Term




CD4 Effector T Cells

Definition

Naive CD4 T Cell

(Uncommitted)

Proliferating T Cell

Immature Effector T Cell (Th0)

Th1 or Th2 

Term

 

 

 

Th1 Cell

Definition

-Activates Macrophages

 

- induces B cells to produce opsonizing antibodies

Term

 

 

 

Th2 Cells

Definition

-Activates B cells to produce neutralizing antibodies

 

- has various effects on macrophages

Term




TH1 Decision Making

Definition

TH1 Decision making

 

- Viruses and some bacteria induce IL-12 secretion by dendritic cells that can activate NK cells to produce IFN-γ

 

- Naive CD4 T cells in the presence of IL-12 and IFN-γ are committed to becoming TH1

 

-Activated TH1 cells secrete IFN-γ

 

-IFN-γ acts on TH2 cells to inhibit proliferation 

Term

 

 

 

TH2 Decision Making

Definition

-Other pathogens (worms) do not induce IL-12 expression by dendritic cells but may cause NK1.1 T Cells to synthesize and secrete IL-4

 

-Naive CD4 T Cells activated in the presences of IL-4 are differentiated into TH2

 

-Activated TH2 Cells secrete IL-10 and TGF-Β

 

-IL-10 and TGF-B act to inhibit growth and activation of TH1 Cells

Term




TH1 Function

Definition

TdTH secretes:

 

Cytokines: IL-2, IL-3, IFN-γ, GM-CSF, TNF-β

 

Chemokines: IL-8, MCAF, MIF

 

Effects on Macrophage activation:

 

↑ Class II MHC Molecules

↑ TNF Receptors

↑ Oxygen Radicals

↑ Nitric Oxide

 


Term




Th17 Cells

Definition

-Newly recognized subset of CD4+ T cells
-Named for their production of IL-17
-Key cytokines produced include IL-17, IL-21 and IL-22
-Involved in autoimmune diseases such as Multiple Sclerosis
-Play key role in anti-microbial immunity
-IL-17 is a key recruiter of neutrophils
-IL-22 induces anti-microbial protein production by epithelial cells

Term



Treg Cells
Definition

-Characterized by CD4, CD25 and FoxP3 expression
-Generally involved in down-regulating immune responses
-Produce TGF-beta and IL-10
-Critical for the prevention of autoimmune diseases

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