Term
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Definition
-Usually first to arrive at site of inflammation
-Ingest antigens and/or pathogens
-Have highly potent killing mechanisms
-Die rapidly following antigen clearance
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Term
Four Types Of Antigen Presenting Cells (APC's) |
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Definition
-Macrophages
-Dendritic cells
-B lymphocytes
-Thymic epithelial cells
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Term
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Definition
-derived (principally) from myeloid lineage, although some dendritic cells are of lymphoid origin.
-ingest antigens and process them for presentation to lymphocytes within lymphoid tissues.
-play an important role in determining the quality and quantity of the specific immune response.
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Term
MHC TYPES FOR CD4 and CD8 |
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Definition
- MHC Type II for CD4
-MHC Type I for CD8
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Term
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Definition
-may capture antigen in infected tissues in the periphery and migrate in the afferent lymphatic vessels into the draining lymph node, where they accumulate in the T cell areas.
-Follicular dendritic cells are localized to the B cell areas and capture antigen that is delivered to the lymph node in complexes with complement or antibodies, and display the antigen intact. |
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Term
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Definition
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T and B Cells
-express antigen-specific receptors.
-mediate effector and regulatory influences.
-confer long-term immunological memory.
-B cells synthesize and secrete antibodies.
-T cells participate in cellular immune responses.
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Term
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Definition
B- Lymphocyte (Anti-body Secretion)
Helper T- Lymphocyte ( Inflammation, Activation of Macrophages and Activation of B, T Cells)
Cytolytic T- Lymphocyte (Target Cell Lysis)
Natural Killer Cell (Target Cell Lysis) |
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Term
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Definition
- large granular lymphocytes.
-recognize damaged cells through alterations to host cells.
-kill damaged cells through cytolytic mechanisms.
-Produce key cytokines that help determine the nature of the immune response
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Term
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Definition
-Sites where cellular components of immunity are generated.
-Precursor cells are generated in the fetal liver during prenatal development.
-Precursor cells are generated in the bone marrow postnatally.
-B lymphocytes (antibody production) mature exclusively in the bone marrow.
-T lymphocytes (damaged cell recognition) mature in the thymus.
-Natural killer (NK) cells (damaged cell recognition) also mature in the bone marrow.
-Myeloid cells (APC precursors) mature in the bone marrow.
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Term
Secondary Lymphoid Tissues |
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Definition
Peripheral Lymph Nodes
-connected to lymphatic network.
-drain peripheral tissues – migration of antigen or APCs into the lymph node.
-compartmentalized to optimize antigen – lymphocyte interactions.
Spleen
-acts as a filter of antigen from the blood.
-the “white pulp” of the spleen is structurally similar to peripheral lymph nodes.
-also designed to optimize antigen – lymphocyte interactions.
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