Term
| _____ is an ATPase that moves along actin filaments by coupling hydrolysis of ATP to conformational changes. |
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Definition
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Term
| Myosin --- powers muscle contraction and cytokinesis? |
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Definition
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Term
| Myosin ___ plays a key role in cytoskeleton interactions? |
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Definition
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Term
| The neck region of myosin is ------ and is associated with the light chains |
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Definition
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Term
| T/F. Myosin can be dimetric or monometric? |
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Definition
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Term
| What region of myosin has binding sites that promote specific activities like myosin I and V binding to the plasma membrane or membranes of intracellular organelles. (Promotes specificity) |
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Definition
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Term
| All myosin responds calcium, so what determines the difference in response? |
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Definition
| Differences in their light chains |
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Term
| What are the names of the light chains of myosin II? |
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Definition
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Term
| T/F. Myosin I and V can be attached at the tail region to either the cell membrane or the membrane of vesicles? |
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Definition
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Term
| Where is the ATP binding pocket of myosin located? |
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Definition
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Term
| How many steps does myosin take per ATP hydrolyzed? |
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Definition
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Term
| Binding of ATP to myosin head has what effect? |
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Definition
| Releases the head from the actin filament |
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Term
| What event causes the "power stroke" of myosin? |
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Definition
| Release of inorganic phosphate |
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Term
| What cocks the head of myosin? |
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Definition
| The hydrolysis of ATP without release of P. |
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Term
| What kind of helix is the tail region of myosin? |
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Definition
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Term
| Does myosin move in a hand over hand method or step by step? |
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Definition
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Term
| During contrition the sacromeres of the myofibrils are contraction to about ____ percent? |
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Definition
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Term
| Myofibrils consist of single base units of ____? |
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Definition
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Term
| What connects myosin to the Z disk, giving muscle its elasticity. |
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Definition
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Term
| Non-elastic fibers that run along actin and connect actin to the Z disk are called ---? |
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Definition
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Term
| What regulates how long that actin filament is before it’s capped? |
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Definition
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Term
| T/F. All the sarcomeres are the same length? |
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Definition
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Term
| After contraction, what protein is responsible for muscles cells relaxing in the absence of ATP and Calcium? |
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Definition
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Term
| Where is calcium stored in muscles cells? |
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Definition
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Term
| T/F. Sacroplasmic reticulum wraps the sacromere? |
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Definition
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Term
| What protein covers up myosin binding sites on actin? |
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Definition
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Term
| What complexes with calcium to move tropomyosin out of the myosin binding sites? |
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Definition
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Term
| T/F. Mysoin can bind actin even in the off state? |
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Definition
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Term
| What prevents myosin from sliding on actin in the off state? |
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Definition
| Troponin-Tropomyosin complex. |
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Term
| Myosin regulatory chains can also be affects by calcium and ____ to either induce or inhibit contraction? |
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Definition
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Term
| What mysoins are used in cytokinesiss? |
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Definition
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Term
| Phosphorylation of Myosin light chains results in ? |
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Definition
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Term
| Phosphorylation of light chains is used in cell movement and cytokinesis. Fact. |
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Definition
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Term
| Know Rho as well as WASP are GTPases that are involved in cell movement. |
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Definition
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Term
| ___ are mostly responsible for the beating of cilia and movement of vesicles? |
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Definition
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Term
| ___ are responsible for cell to cell division? |
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Definition
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Term
| Microtubules of made up of ___ subunits? |
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Definition
| Heterodimers. Alphan and Beta tubulin. |
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Term
| What is the role of gamma tubulin in respect to microtubules? |
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Definition
| Nucleates A and B tubulin |
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Term
| How many does tubulin subunit bind? |
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Definition
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Term
| One GTP binds the ___-tubulin and it binds irreversibly and is not hydrolyzed. |
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Definition
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Term
| The other GTP binds reversibly to b-tubulin and is hydrolyzed. Therefore, tubulin is a ____? |
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Definition
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Term
| ___ tubulin is associated with the positive end and ___ tubulin is associated with the minus end? |
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Definition
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Term
| What enzyme used in cancer treatments inhibits microtubules? |
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Definition
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Term
| Microtubule polymerization occurs preferientially at which end above the critical concentration? |
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Definition
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Term
| T/F. Cooler temperatures also slow down polymerization of microtubules? |
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Definition
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Term
| Tau is an example of a ---- protein? |
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Definition
| MAP. Microtubule associated Protein. |
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Term
| --- proteins can determine how closely packed microtubules become within the cell? |
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Definition
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Term
| Kinesin ___ is used to slide microtubules in opposite directions? |
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Definition
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Term
| ___ links dyneins to the transport material? |
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Definition
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Term
| During cell division, cdc2 kinase induces the disassembly of IF by ___? |
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Definition
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Term
| One example is ____, which is a member of plakin family of IFAPs that link IFs to microtubules and microfilaments. |
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Definition
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