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BSI Pathway Cards
BSI Pathway Cards from 17 on
31
Physiology
Graduate
09/24/2013

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Term
PLA2 produces
Definition
Arachidonic acid
Term
Arachidonic acid is the precursor to..
Definition
COX enzymes (cyclooxygenase)
Term
Cyclooxygenase produces
Definition
cyclic endoperoxides such as the prostaglandins and thromboxanes
Term
Required to Initiate Cell Cycle
Definition
Mitogen binding
Term
CdKs Function
Definition
Phosphorylate key proteins
Term
G1-CdK and G1/S-CdK lead to
Definition
S-phase & activation of S-CdK
Term
M-CdK
Definition
transition through M phase
Term
Mitogen Signaling
Definition
Increased activity of G1-CdK and G1/S-CdK
Term
Rb phosphorylation
Definition
release of E2F & entry into S phase
Term
E2F
Definition
a transcription factor that increases expression of proteins needed for S-phase
Term
G1-CdK and G1/S-CdK phosphorylate
Definition
Rb
Term
How does activation of G1-CDK and G1/S-CDK lead to activation of S-CDK and entry into S phase?
Definition
G1-CdK and G1/S-CdK phosphorylate Rb. Rb leads to release E2F, and E2F pushes to S phase
Term
How is G1-CDK and G1/S-CDK activated from mitogen binding?
Definition
Mitogen binding leads to stimulation of Ras/MAPK pathway. MAPK activates a gene regulatory protein (transcription factor), which increases myc. Myc regulates Cyclin D, SCF, and E2F. Cyclin D expression leads to the activation of G1-CDK, SCF degrades p27 which will lead to more G1/S-CdK, E2F pushes to S phase
Term
How does the cell prevent entry into S phase if there is DNA damage?
Definition
DNA damage leads to activation of a kinsase (ATM or ATR) which then phosphorylates p53. p53 increases p21, p21 binds to G1/S-CdK and S-CdK inhibiting their activity
Term
p53
Definition
increases p21
Term
MDM2
Definition
ubiquinates (degrades) p53
Term
p21
Definition
binds to G1/S-CdK and S-CdK inhibiting their activity
Term
CAK/Wee1
Definition
phosphorylate M-CDK (CAK = activating phosphate, Wee1 = inhibitory phosphase)
Term
M-cyclin
Definition
binds to M-CDK forming the M-CDK complex
Term
S-CdK
Definition
Phosphorylates Cdc25
Term
Cdc25
Definition
removes the inhibitory phosphate that Wee1 added to activate M-CdK
Term
M-CDK regulates..
Definition
most events in M phase, such as APC activation and chromosomal segregation
Term
p27
Definition
inhibits activation of G1/S-CDK
Term
SCF
Definition
degrades p27, so increase of G1/SCdK
Term
APC
Definition
ubiquinates securin
Term
securin
Definition
inhibits separase
Term
ATM/ATR
Definition
kinases that phosphorylate p53 so mdm2 will stay bound and keep degrading p53
Term
Transcription Factors
Definition
E2F, p53, myc, unnamed that MAPK activate
Term
Ubiquitin ligases
Definition
SCF (ubiquinates p27), mdm2 (ubiquinates p53), APC (ubiquinates securin
Term
separase
Definition
pulls the sister chromatids apart
Term
cdc20
Definition
activates APC
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