Term
| Cyclin-dependent kinases abbreviation |
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Definition
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Term
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Definition
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Term
| CdK's phosphorylate key proteins involved in the _____ |
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Definition
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Term
| Phosphorylate key proteins involved in the cell cycle |
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Definition
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Term
| Must be bound to cyclins in order to be activd |
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Definition
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Term
| CdKs must be bound to ____ in order to be active |
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Definition
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Term
| cdKs must be bound to cyclins in order to be ____ |
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Definition
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Term
| When cyclins are degraded the ___ become inactive |
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Term
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Definition
| ubiquitin-proteasome system |
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Term
| ___ are degreaded by the Ubiquitin-proteasome system |
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Definition
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Term
| There are a variety of CdKs and cyclins that regulate: |
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Definition
| The different phases of the cell cycle |
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Term
| The cyclin-CdK complex are called: |
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Definition
| G1-CDK, G1/S-CDK, S-CdK, and M-CdK |
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Term
| the _____ are called G1-CDK, G1/S-CDK, S-CdK, and M-CdK |
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Definition
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Term
| Aside from cyclin binding, CdKs also require _____ / ____ to be fully active |
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Definition
| Phosphorylation/dephosphorylation |
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Term
| Aside from cyclin binding, CdKs also require phosphorylation/dephosphorylation to: |
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Definition
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Term
| Early in G1 no _____ are active |
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Definition
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Term
| In mammals an external cellular signal (mitogen) is required to: |
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Definition
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Term
| In mammals an external cellular signal (____) is required to initiate the cell cycle. |
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Definition
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Term
| In _____ an external cellular signal (mitogen) is required to initiate the cell cycle. |
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Definition
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Term
| The mitogen stimulated activity of ____ and ____ which leads to transition into S phase and activation of S-CdK |
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Definition
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Term
| The mitogen stimulated activity of G1-CdK and G1/S-CdK which leads to: |
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Definition
| Transition into S phase and activation of S-CdK |
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Term
| M-CdK activity is responsible for transition through the _____ |
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Definition
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Term
| ___ activity is responsible for transition though the M-phase |
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Definition
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Term
| ______ signaling leads to increased activity of G1-CdK and G1/S-CdK |
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Definition
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Term
| Mitogen signaling leads to increased activity: |
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Definition
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Term
| Rb phosphorylation leads to increased activity of E2F and entry into _____ |
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Definition
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Term
| _____ leads to increased activity of E2F and entry into S-phase |
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Definition
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Term
| Rb phosphorylation leads to increased activity of ____ and entry into S-phase |
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Definition
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Term
| E2F is a transcription factor that increases expression of proteins needed for _____ |
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Definition
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Term
| ____ is a transcription factor that increases expression of proteins needed for S-Phase |
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Definition
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Term
| E2F is a ______ that increases expression of proteins needed for S-Phase |
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Definition
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Term
| How does activation of G1-CDK and G1/S-CDK lead to activation of S-CDK and entra into S phase? |
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Definition
1) G1-CDK and G1/S-CDK phosphorylates Rb
2) Phosphorylation of Rb leads to the release of E2F
3) E2F is a transcription factor that regulates the transcription of genes necessary for S-phase |
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