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BSci 112A Unit 2
Protein Transport, Metabolism
5
Biology
Undergraduate 2
09/28/2010

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Proteins that leave the cytosol have intrinsic sorting signals that direct them to the appropriate organelle.

Definition

 

 

 

 

The Signal Hypothesis

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Sorting signals can be part of these levels of protein structure.

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Primary, Secondary, Tertiary, Post-translational modification

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Three mechanisms for protein -> organelle delivery

Definition

 

 

1) Gated Transport - Fully folded proteins pass through a large pore ex. nuclear pore

 

2) Translocation -  Unfolded proteins are threaded through a translocon (small pore); membrane remains impermeable to small molecules ex. ER, mitochondria, chloroplasts

 

3) Vesicular Transport - Proteins move between organelles without crossing a membrane while carried by small membrane-bound vesicles ex. secretory and endocytic pathways

 

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A short residue sequence that is recognized by a receptor that delivers the fully-folded peroxisomal protein through a membrane gate/pore.

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Peroxisomal Targeting Sequence

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This is the only organelle where ribosomes and mRNA are delivered directly.

 

 

 

 

Definition

 

 

 

 

 

ER

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