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Borrelia
BBD Lec 4/7 @11:30AM
28
Medical
Professional
04/07/2010

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Term
Describe the general properties of the bacteria associated with the genus Borrelia, including the physiology and structure of the organism.

Describe the basic features of the pathogenesis and immunity associated with Lyme disease and relapsing fever.

Describe the basic aspects of the epidemiology and clinical manifestations associated with Lyme disease and relapsing fever.

Compare the modes of transmission of the Lyme disease and relapsing fever.

Describe the diagnosis, treatment and control of Lyme disease and relapsing fever.

Describe the approach to diagnosis and treatment and control of relapsing fever and Lyme disease.
Definition
LOs
Term
Where and when was Lyme disease discovered?
Definition
1977 in Lyme, CT. Caused by Borrelia burgdorferi (named after the guy who found it)
Term
what does Borrelia recurrentis cause?
Definition
relapsing fever
Term
structure of Borrelia?
Definition
gram neg. bacilli. cannot be cultured. look like spirochetes
Term
T/F : the genome is linear and present in mulitple copies in B. burgdorferi
Definition
True
Term
what is the leading vector-borne disease in the USA?
Definition
Lyme Disease
Term
can humans spread Lyme disease?
Definition
no. they are accidental hosts.
Term
what is Ixodes scapularis?
Definition
the tick that transmits Lyme disease.
Term
what are the maintenance hosts of lyme disease?
Definition
rodents and deer
Term
what are the incidental hosts of the lyme disease?
Definition
humans
Term
how long is the maturation cycle of Ixodes scapularis?
Definition
TWO years
Term
is the bacteria transmitted to the larvae of the infected tick?
Definition
NO!
Term
how are new ticks infected?
Definition
they bite an infected rodent/deer.
Term
when do these ticks lay their eggs?
Definition
Spring
Term
what animal do the ticks mate on?
Definition
deer
Term
how many stages are present in clinical manifestations of Lyme Disease?
Definition
3
Term
what is erythema migrans?
Definition
diagnostic "bulls-eye" rash of Lyme Disease
Term
what are other symptoms in the 1st stage of lyme disease aside from the erythema migrans?
Definition
Influenza-like: malaise, chills, fever, headache, joint and muscle pains.
Term
what two systems are involved in the second stage of lyme disease?
Definition
heart and nervous
Term
what symptoms are seen in the third stage of lyme disease?
Definition
about 6months after skin rash, you see joint pain, swelling and tenderness.
Term
why is it difficult to detect bacteria in blood and tissues after a few weeks (following an intense immune response)?
Definition
bacteria have the ability to switch antigens. The immune response is probably responsible for the symptoms of the second and third stages.
Term
how long do the ticks need to feed to transmit an infective dose?
Definition
1-2 days (24-48 hours)
Term
lice vs. louse?
Definition
plural vs. singular
Term
differences between epidemic and endemic relapsing fever?
Definition
slide 50-51
Term
how many relapses with epidemic form? with the endemic form?
Definition
single. multiple.
Term
where can i find a good summary of Rickettsia and Borrelia?
Definition
slide 55
Term
if its an epidemic, is it louse or tick borne?
Definition
louse
Term
if its an endemic, is it louse or tick borne?
Definition
tick
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