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Board Prep Rheumatology
Board Prep Rheumatology
22
Pharmacology
Graduate
03/27/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
What Chemotactic agent is specific for Neutrophils?
Definition

LTB4

 

"Neutrophils arrive B4 others"

Term
What Leukotriens function in bronchoconstriction, vasoconstriction, contraction of smooth muscle, and increase vascular permeability?
Definition
LTC4, D4, and E4
Term

What Arachidonic Acid products cause:

 

↓ Platelet aggregation

↓ Vascular tone

↓ Bronchial tone

↓ Uterine tone

Definition

Prostacyclin


PGI2

Term

What Arachidonic Acid products cause:


↑ Uterine Tone

↓ Vascular Tone

↓ Bronchial Tone

Definition

Prostaglandins

 

PGE2

PGF

Term

What Arachidonic Acid products cause:


↑ Platelet Aggregation

↑ Vascular Tone

↑ Bronchial Tone

Definition

Thromboxane

 

TXA2

Term
What NSAID is used to close a PDA?
Definition
Indomethacin
Term

Where is COX2 to found and what does it mediate?

 

What drug specifically inhibits COX2?

Definition

COX2 is found in inflammatory cells and vscular endothelium 

 

Mediates inflammation and Pain

 

Celecoxib

Term

What antiinflammatory drug has an increase risk of thrombosis but is less toxic to GI mucosa?

 

What is it used to treat?

 

Definition

Celecoxib

 

Rheumatoid and Ostoarthritis

in patients with gastritis or ulcers

Term
What drug reversibly inhibts clyclooxygenase, mostly in CNS, so lacks antiinflammatory properties?
Definition

Acetaminophen

 

Used instead of aspirin to prevent Reye's Syndrome in children with viral infection

Term

What kind of toxicity can an overdoes of Acetaminophen cause? 

 

How is this treated?

Definition

Hepatic Necrosis

 

Acetaminophen metabolite depletes glutathione 

 

N-acetylcysteine

Regenerates glutathione

Term
What drugs inhibit osteoclastic activity to reduce both formation and resorption of hydroxyapatite?
Definition

Bisphosphonates

 

Etidronate

Pamidronate

Alendronate

Risedronate

Zoledronate

Term

Why should the Bisphosphonates be taken 30 minutes prior to lying down?

 

Etidronate

Pamidronate

Alendronate

Risedronate

Zoledronate

Definition

Corrosive Esophagitis

(Except Zoledronate)

 

Can also cause:

Nausea

Diarrhea

Osteonecrosis of the Jaw

 

 

Term
What drugs are used in the treatment of Gout?
Definition

Chronic Gout:

 

Probenecid

Allopurinol

Febuxostat

 

Acute Gout:

 

Colchicine

NSAIDs

Term

What chronic gout drug inhibits reabsorption of uric acid in the PCT?

 

What drug should be avoided with this drug?

Definition

Probenecid

 

Penicillin

(also prevents it's secretion) 

Term
What chronic gout drug inhibits xanthine oxidase, decreasing conversion of xanthine to uric acid?
Definition

Allopurinol

 

 

Term
What drug can be used in lymphoma and leukemia to prevent turmor lysis-associated urate nephropathy?
Definition
Allopurinol
Term
What 2 drugs, that are metabolized by xanthine oxidase, have increased concentrations when use with Allopurinol? 
Definition

Azathioprine

 

6-MP

Term
What Acute gout drug binds and stabilizes tubulin to inhibit polymerization, impairing leukocyte chemotaxis and degranulation?
Definition
Colchicine
Term

What are the TNF-α inhibitors? 

 

What are they used to treat?

Definition

Etanercept

Infliximab

Adalimumab


Clinical Use:

Rheumatoid arthritis

Psoriasis

Ankylosing Spondylitis

Crohn's Disease

Term
What TNF-α inhibitor is recombinant form of human TNF receptor that acts as a decoy to TNF?
Definition

Etanercept

 

Term
What drugs are Anti-TNF antibodies?
Definition

Infliximab

Adalimumab

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