Term
| What Chemotactic agent is specific for Neutrophils? |
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Definition
LTB4
"Neutrophils arrive B4 others" |
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Term
| What Leukotriens function in bronchoconstriction, vasoconstriction, contraction of smooth muscle, and increase vascular permeability? |
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Definition
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Term
What Arachidonic Acid products cause:
↓ Platelet aggregation
↓ Vascular tone
↓ Bronchial tone
↓ Uterine tone |
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Definition
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Term
What Arachidonic Acid products cause:
↑ Uterine Tone
↓ Vascular Tone
↓ Bronchial Tone |
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Definition
Prostaglandins
PGE2
PGF2α |
|
|
Term
What Arachidonic Acid products cause:
↑ Platelet Aggregation
↑ Vascular Tone
↑ Bronchial Tone |
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Definition
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Term
| What NSAID is used to close a PDA? |
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Definition
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Term
Where is COX2 to found and what does it mediate?
What drug specifically inhibits COX2? |
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Definition
COX2 is found in inflammatory cells and vscular endothelium
Mediates inflammation and Pain
Celecoxib |
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Term
What antiinflammatory drug has an increase risk of thrombosis but is less toxic to GI mucosa?
What is it used to treat?
|
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Definition
Celecoxib
Rheumatoid and Ostoarthritis
in patients with gastritis or ulcers |
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Term
| What drug reversibly inhibts clyclooxygenase, mostly in CNS, so lacks antiinflammatory properties? |
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Definition
Acetaminophen
Used instead of aspirin to prevent Reye's Syndrome in children with viral infection |
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Term
What kind of toxicity can an overdoes of Acetaminophen cause?
How is this treated? |
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Definition
Hepatic Necrosis
Acetaminophen metabolite depletes glutathione
N-acetylcysteine
Regenerates glutathione |
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Term
| What drugs inhibit osteoclastic activity to reduce both formation and resorption of hydroxyapatite? |
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Definition
Bisphosphonates
Etidronate
Pamidronate
Alendronate
Risedronate
Zoledronate |
|
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Term
Why should the Bisphosphonates be taken 30 minutes prior to lying down?
Etidronate
Pamidronate
Alendronate
Risedronate
Zoledronate |
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Definition
Corrosive Esophagitis
(Except Zoledronate)
Can also cause:
Nausea
Diarrhea
Osteonecrosis of the Jaw
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Term
| What drugs are used in the treatment of Gout? |
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Definition
Chronic Gout:
Probenecid
Allopurinol
Febuxostat
Acute Gout:
Colchicine
NSAIDs |
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Term
What chronic gout drug inhibits reabsorption of uric acid in the PCT?
What drug should be avoided with this drug? |
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Definition
Probenecid
Penicillin
(also prevents it's secretion) |
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Term
| What chronic gout drug inhibits xanthine oxidase, decreasing conversion of xanthine to uric acid? |
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Definition
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Term
| What drug can be used in lymphoma and leukemia to prevent turmor lysis-associated urate nephropathy? |
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Definition
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Term
| What 2 drugs, that are metabolized by xanthine oxidase, have increased concentrations when use with Allopurinol? |
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Definition
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Term
| What Acute gout drug binds and stabilizes tubulin to inhibit polymerization, impairing leukocyte chemotaxis and degranulation? |
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Definition
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Term
What are the TNF-α inhibitors?
What are they used to treat? |
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Definition
Etanercept
Infliximab
Adalimumab
Clinical Use:
Rheumatoid arthritis
Psoriasis
Ankylosing Spondylitis
Crohn's Disease |
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Term
| What TNF-α inhibitor is recombinant form of human TNF receptor that acts as a decoy to TNF? |
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Definition
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Term
| What drugs are Anti-TNF antibodies? |
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Definition
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