Term
What are the H1 Blockers?
What are their uses? |
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Definition
1st Generation
Diphenhydramine
Dimenhydrinate
Chlorpheniramine
Clinical Use:
Allergy, motion sickness, sleep aid
2nd Generation
Loratadine
Fexofenadine
Desloratadine
Cetirizine
Clinical Use:
Allergy |
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Term
| What are the 2 ways asthma therapy is directed? |
|
Definition
1. Inflammatory processes
2. Sympathetic Tone |
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Term
| What drugs are specific β2-agonist used for asthma treatment? |
|
Definition
Albuterol
(for acute exacerbation)
Salmeterol
(Long acting for prophylaxis) |
|
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Term
| What asthma drug causes bronchodilation by inhibiting phosphodiesterase → ↓cAMP hydrolysis? |
|
Definition
Theophylline
(narrow therapeutic index) |
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Term
What drug has a narrow therapeutic index and can cause cardiotoxicity and neurotoxicity?
What is this drug metabolized by? |
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Definition
Theophylline
Metabolized by P-450
Blocks actions of adenosine |
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Term
What drug competitivly blocks muscarinic receptors, preventing bronchoconstriction?
What is this drug used for? |
|
Definition
Ipratropium
Used for Asthma and COPD |
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Term
| What drug is used for asthma prophylaxis and prevents the release of mediators form mast cells? |
|
Definition
|
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Term
| How do Beclomethasone and Prednisone decrease inflammation in chronic asthma? |
|
Definition
Inhibit synthesis of cytokines
Inactivate NF-κB - transcription factor that induces the production of TNF-α |
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Term
| What antileukotrienes blocks conversion of arachidonic acid to leukotrienes? |
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Definition
|
|
Term
What Antileukotrienes block leukotriene receptors?
What type of asthma are they especially good for? |
|
Definition
Zafirlukast
(good for 5 YO and up)
Montelukast
(good for 1 YO and up)
Especially good for aspirin-induced asthma |
|
|
Term
| What expectorant agent cna loosen mucous plugs in CF patients? |
|
Definition
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|
Term
What drug is used in asthma challenge testing?
What type of agent is it? |
|
Definition
Methacholine
Muscarinic receptor agonist |
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