Term
| What antidepressants Block reuptake of NE and serotonin, but can have side effects of Convulsions, Coma and Cardiotoxicity? |
|
Definition
Tricyclic Antidepressants
Amitriptylin
Nortriptyline
Imipramine
Desipramine
Clomipramine
Doxepin
Amoxapine
Used For:
Major Depression, Bedwetting(imipramine), OCD(clomipramine), fibromyalgia
|
|
|
Term
| What TCA is used for the bedwetting? |
|
Definition
|
|
Term
| What TCA is used for OCD treatment? |
|
Definition
|
|
Term
| Which TCA is the least sedating and has lower seizure threshold? |
|
Definition
|
|
Term
Which TCAs have more anticholinergic effects?
(tachycardia, urinary retention) |
|
Definition
3º TCAs (Amitriptyline) > 2º TCAs (Nortriptyline) |
|
|
Term
| What are the Serotonin-specific reuptake inhibitors? |
|
Definition
SSRIs
Fluoxetine
Paroxetine
Sertraline
Citalopram
Used for:
Depression, OCD, bulimia, social phobias, PTSD |
|
|
Term
| What is Serotonin Syndrome, what is it cause by? |
|
Definition
Serotonin Syndrome
Hyperthermia, myoclonus, cardiovascular collapse, flushing, diarrhea, seizures
Caused by any combination of drugs that ↑ serotonin
(SSRIs, MAOIs) |
|
|
Term
What are the SNRIs?
What is their mechanism? |
|
Definition
SNRIs
Venlafaxine, Duloxetine
MOA:
Inhibit Serotonin and NE reuptake |
|
|
Term
Which SNRI is used in generalized anxiety disorder?
Which SNRI is indicated for diabetic peripheral neuropathy? |
|
Definition
Generalized Anxiety Disorder:
Venlafaxine
Diabetic peripheral neuropathy:
Duloxetine |
|
|
Term
| Which SNRI has a greater effect on NE? |
|
Definition
|
|
Term
What are the MAO Inhibitors?
What is their effect? |
|
Definition
MAOIs
Tranylcypromine
Phenelzine
Isocarboxazid
Selegiline (MAO-B inhibitor)
Effect:
Nonselective MAO inhibition ↑ levels of amine neurotransmitters |
|
|
Term
What drugs are used in the treatment of:
Atypical Depression
Anxiety
Hypochondriasis |
|
Definition
MAOIs
Tranylcypromine
Phenelzine
Isocarboxazid
Selegiline |
|
|
Term
| What type of food should be avoided when taking MAOIs? |
|
Definition
High Tyramine Foods
wine and cheese |
|
|
