Term
| What is subacute bacterial endocarditis? |
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Definition
A gradual illness that can result in stroke. A biofilm of normal flora forms, usually S. epidermis or sometimes veridians
- Dental procedures, heart deformities a risk. Can form an abscess |
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Term
| What is gram-negative septicemia? |
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Definition
Violent chills and fever that can lead to shock. Very high mortality rate.
- E. coli, gram(-)
- P. aeruginosa, gram(-)
- Bacteroides, gram(-) |
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Term
| What is the pathogenesis of gram-negative septicemia? |
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Definition
bacteria enter the bloodstream and release endotoxin. Macrophages respond. LUNGS very susceptible to damage
**A nosocomial disease |
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Term
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Definition
"Rabbit fever" - skin ulcers and enlarged lymph nodes caused by Francisella tularensis, gram(-).
- Spreads from animal carcasses. A vaccine exists. Tx with gentamicin |
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Term
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Definition
"Undulant Fever" - achy, enlarged lymph nodes, weight loss. Caused by Brucella melitensis, all from animals
**Causes endocarditis and osteomyelitis. Contaminates milk and meat. Meat-packing industry. Tx w/ tetracycline & rifampin |
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Term
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Definition
"Black Death" from a flea bite. Lymph nodes called buboes, high fever, bleeding under the skin, bloody cough
- Caused by Yersinia pestis |
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Term
| What are the plasmids in Yersinia pestis? |
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Definition
- Pla - activates plasminogen factor to dissolve clots. To spread from entry site
- Yops - stops phagocytosis. Enhance survival
- F1 - capsule stops phagocytosis, used in vaccine. Multiply in macrophages |
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Term
| What are the causative agents of blood infections? |
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Definition
- Subacute bacterial endocarditis - S. epidermis
- gram(-) septicemia - E. coli, P. aeruginosa, Bacteroides
- Tularemia - Francisella tularensis
- Brucellosis - Brucella melitensis
- Black Death - Yersinia pestis |
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