Shared Flashcard Set

Details

Blood Bank Exam 1 Lecture 4
Blood Bank Exam 1 Lecture 4 Study Material
19
Biology
Undergraduate 3
01/21/2015

Additional Biology Flashcards

 


 

Cards

Term
3 reasons why forward and reverse do not agree
Definition
Reagents
Wrong Sample
Testing Errors
Term
What all patient information should you consider after technical errors have been ruled out?
Definition
age
drugs
diseases
transfusion history
Term
Mixed Field Agglutination
Definition
When some cells are in small or tiny clumps but other cells are free
Term
4 Types of Forward or Cell Typing - Additional Reactions or Antigens Discrepancies
Definition
Polyagglutinable and nonspecific agglutination
Acquired B
Sensitized RBCs
2 Blood Populations
Term
Polyagglutinable and nonspecific agglutination
Definition
Removal of sialic acid from the cell by bacteria enzymes can expose something called T AGN on the surface
Term
Acquired B
Definition
Bacterial enzyme cleaves off the active group of A making it look like B AGN and could react with B antisera
Term
Sensitized RBCs
Definition
Protein in typing reagents can reduce the zeta potential enough to cause false reactions
Term
Two blood populations
Definition
After transfusion of wrong blood
Chimera-mixture of blood between twins
Term
2 types of Forward Cell Typing - Missing AGNs
Definition
1. Subgroups of A do not always react with A typing sera
2. Altered or weakened AGN expression by certain diseases
Term
What is the main problem with subgroups of A not reacting with A typing sera
Definition
Subgroup A is called O and given to an O person who then dies
Term
4 reasons for Reverse typing - additional reactants or ABYs
Definition
Cold Alloantibodies
Rouleaux
Subgroups with Anti A1
Cold Autoantibodies
Term
Cold Alloantibodies
Definition
be in patient serum could react with reagent cells if they expressed the Ag - i.e., M, P, Le
Term
Rouleaux
Definition
Replace plasma with saline
Term
Subgroups with Anti-A1
Definition
Use Lectin and A2 Cells
Term
What is the Most Common Discrepancy in a healthy person?
Definition
Subgroups with anti-A1
Term
Most frequent cause for Reverse Typing - Missing ABYs
Definition
Weak or missing ABYs such as in babies, the elderly, or the immunocompromised
Term
Weak reactions can be intensified by testing at _____ which is optimum temp for anti A and B
Definition
4 degrees Celsius
Term
How do you know which reaction is correct?
Definition
Strength of reaction
Most common causes
whole picture of results and patient history/age
Term
6 things to do if you experience a discrepancy
Definition
-Wash RBCs well
-Test cells with A, B, & Anti-A1
-Test Plasma with A1, A2, B, and O cells as well as with auto and cord cells
-Examine under scope to look for mfa or rouleaux
-Incubate at RT for 30 minutes
-Get clinical information
Supporting users have an ad free experience!